Recruiting NCT04645628
Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MRI examination.
- Who it may be relevant to
- Registry conditions: Healthy Subjects, Patient Performing an MRI Examination. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The purpose of this study is to evaluate the optimization of MRI acquisition sequences.
Interventions
- Other MRI examination
All subjects (healthy subjects and patients) will have an MRI examination with optimized sequences
Primary outcome measures
- Image quality based on standard imaging quality criteria. [Time frame: 6 months after the last inclusion]
Secondary outcome measures (7)
- Comparison of the Signal to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence). [Time frame: 6 months after the last inclusion]
- Comparison of the Contrast to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence). [Time frame: 6 months after the last inclusion]
- Comparison of the acquisition time obtained with the optimized MRI sequence and the reference situation (standard sequence). [Time frame: 6 months after the last inclusion]
- Comparison of blurring and artefacts obtained by the optimized MRI sequence and the reference situation (standard sequence). [Time frame: 6 months after the last inclusion]
- Comparison of the spatial resolution obtained by the optimized MRI sequence and the reference situation (standard sequence). [Time frame: 6 months after the last inclusion]
- Qualification of the MRI acquisition for a clinical study. [Time frame: 6 months after the inclusion]
- Evaluation of intra-subject reproducibility on the same MRI and on two MRIs. [Time frame: 6 months after the last inclusion]
Eligibility criteria
Inclusion Criteria for all subjects :
- to be over 18 year-old,
- to be able to understand the instructions given,
- to be enrolled in a social security plan,
- to have underwent a pre-inclusion medical examination,
- to give a written consent.
Inclusion Criteria especially for Patients :
- to perform a MRI examination of the head, neck, spine, thorax, abdomen, pelvis, retroperitoneum, lower limbs, upper limbs or whole body during clinical follow-up care.
Exclusion Criteria for all subjects :
- any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ),
- subject under a measure of legal protection.
Exclusion Criteria especially for Healthy Subjects :
- to have a pathology in the anatomical area to be imaged
- to be employed by the CHRU of Nancy or having the slightest link of subordination with the CHRU of Nancy.
Exclusion Criteria especially for Patients :
- to have a limited MRI examination time due to a sensitive clinical situation (sedation, unstable hemodynamic state, postoperative).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 1 center
- CHRU de Nancy — Nancy
Publications
- He Z, Soullie P, Lefebvre P, Ambarki K, Felblinger J, Odille F. Changes of in vivo electrical conductivity in the brain and torso related to age, fat fraction and sex using MRI. Sci Rep. 2024 Jul 12;14(1):16109. doi: 10.1038/s41598-024-67014-9. PMID 38997324
- Caron B, Laurent V, Odille F, Danese S, Hossu G, Peyrin-Biroulet L. New magnetic resonance imaging sequences for fibrosis assessment in Crohn's disease: a pilot study. Scand J Gastroenterol. 2022 Dec;57(12):1450-1453. doi: 10.1080/00365521.2022.2094727. Epub 2022 Sep 29. PMID 36173349
- Boubaker F, Lane JI, Puel U, Drouot G, Witte RJ, Ambarki K, Gondim-Teixeira PA, Blum A, Parietti-Winkler C, Vallee JN, Gillet R, Eliezer M. High-Resolution 3T MRI of the Membranous Labyrinth Using Deep Learning Reconstruction. AJNR Am J Neuroradiol. 2026 Mar 4;47(3):723-729. doi: 10.3174/ajnr.A8989. PMID 40876943
- Gillet R, Boubaker F, Clara M, Ambarki K, Stemmer A, Drouot G, Gillet P, Gondim Teixeira PA, Blum A. Optimizing knee MRI: 3D proton density turbo spin echo nDixon sequence vs. 2D high-resolution turbo spin echo in half the acquisition time. Eur J Radiol. 2026 Feb;195:112552. doi: 10.1016/j.ejrad.2025.112552. Epub 2025 Nov 19. PMID 41285050
- Wary P, Hossu G, Ambarki K, Nickel D, Arberet S, Oster J, Orry X, Laurent V. Deep learning HASTE sequence compared with T2-weighted BLADE sequence for liver MRI at 3 Tesla: a qualitative and quantitative prospective study. Eur Radiol. 2023 Oct;33(10):6817-6827. doi: 10.1007/s00330-023-09693-y. Epub 2023 May 16. PMID 37188883
- Paillart G, He Z, Romero G, Ferry P, Ambarki K, Soullie P, Felblinger J, Odille F. Improved Radiofrequency Safety Modelling in MRI Using In Vivo Measurements of Brain Conductivity. NMR Biomed. 2026 Aug;39(8):e70335. doi: 10.1002/nbm.70335. PMID 42338094
Identifiers
NCT: NCT04645628 · 2020-A01969-30