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Recruiting NCT04643418

Phase 1/2a Study of MPB-1734 in Patients With Advanced Solid Tumors

Phase I / Phase II Interventional Solid Tumor, Unspecified, Adult

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: MPB-1734.
Who it may be relevant to
Registry conditions: Solid Tumor, Unspecified, Adult. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Taiwan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Phase 1/2a Dose-ranging, Safety, Pharmacokinetics, and Preliminary Efficacy Study of MPB-1734 in Patients With Advanced Solid Tumors in Part 1 and With Selected Solid Tumors in Part 2

Overview

This is a first-in-human (FIH), multicenter, open-label, uncontrolled, Phase 1/2a study with dose escalation in patients with advanced solid tumors (Part 1) and cohorts of up to 15 patients per selected indication (Part 2). The solid tumor types in Part 2 will be decided by the sponsor prior to the start of Part 2, but not be solely based on the efficacy results in Part 1.

Detailed description

This study will occur in two parts, Dose-escalation (Part 1) and Cohort-expansion (Part 2). The main purpose of Part 1 is to determine the doses and dosing schedule of MPB-1734 that is safe and tolerable when given in subjects with certain types of advanced cancer. Part 2 of the study will begin when the Sponsor determines the safe and tolerable doses and dosing schedule from Part 1. The main purpose of Part 2 is to continue to assess the safety and tolerability of the MPB-1734 dose and dosing schedule determined by the Sponsor during Part 1. The preliminary efficacy of MPB-1734 will also be assessed in both Part 1 and Part 2.

Interventions

  • Drug MPB-1734
    Administered once daily in a 21-day cycle

Primary outcome measures

  • Evaluation the the maximum tolerated dose(MTD) by safety data [Time frame: Through the end of the first cycle (Days 1-21).]
Secondary outcome measures (4)
  • Incidence of Treatment-Emergence Adverse Events [Time frame: Approximately 24 weeks]
  • Maximum observed plasma concentration (Cmax) [Time frame: Day 1-Day 2]
  • Area under the plasma concentration-time curve (AUC) [Time frame: Day 1-Day 2]
  • Half-life (T1/2) [Time frame: Day 1-Day 2]

Eligibility criteria

Inclusion criteria

  • Signed informed consent in the local language prior to any study-mandated procedure.
  • Male or female patients at least 18 years of age, at the time of informed consent.
  • Male or nonpregnant and nonlactating female patients with pathologically confirmed, measurable solid tumor lesions (Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST 1.1\]) that are unresectable, and standard therapy able to provide clinical benefit does not exist or is no longer effective.
  • Eastern Cooperative Oncology Group Performance Status ≤2.
  • Patients have recovered from the acute toxicity of previous therapies (peripheral sensory neuropathy recovered to ≤Grade 2) except alopecia, and:
  • At least 4 weeks have elapsed since completing surgery, endocrine therapy, tyrosine kinase inhibitor therapy, immunotherapy, radiotherapy, chemotherapy, and/or
  • At least 6 weeks have elapsed since completing chemotherapy with nitrosoureas, melphalan, and/or mitomycin C, and/or
  • At least 6 weeks have elapsed since completing cranial radiotherapy.
  • Life expectancy of greater than 12 weeks.
  • Ability to communicate well with the investigator, in the local language, and to understand and comply with the requirements of the study.

Exclusion criteria

  • Peripheral sensory neuropathy >Grade 2 (CTCAE version 5.0) at baseline.
  • Patients requiring immediate palliative treatment of any kind including surgery and/or radiotherapy.
  • Serum bilirubin >1.5× ULN.
  • AST and/or ALT >2.5× ULN if no liver involvement, OR AST and/or ALT >5× ULN with liver involvement.
  • Serum creatinine >1.5× ULN, and/or a creatinine clearance of <50 mL/min calculated by Cockcroft Gault.
  • QTc prolongation defined as a QTc with Framingham correction greater than or equal to 470 ms, or significant electrocardiogram (ECG) abnormalities.
  • Known hypersensitivity to taxanes or any excipients of the drug formulation.
  • Female patients who are pregnant, breast-feeding, or planning to become pregnant during the study.
  • Untreated and/or uncontrolled central nervous system metastases.
  • Patients with brain tumors, primary or metastatic.
  • Patients taking concomitant medications anticipated to result in drug-drug interactions.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

Taiwan · 1 center
  • Taipei Veterans General Hospital — Taipei

Identifiers

NCT: NCT04643418 · DMB-CT-001

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗