Efficacy and Safety of Fertility Treatments and Fertility Preservation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: fertility preservation, several methods.
- Who it may be relevant to
- Registry conditions: Infertility. Basic parameters: up to 56 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Studies Aiming at Identifying Predictors for Fertility Treatments' Outcomes and to Evaluate the Efficacy and Safety of Fertility Preservation
Overview
This study analyses clinical data prospectively collected for over a decade in several clinical databases. Electronic medical records are available since 1998. Since 2011 the subgroup of patients that undergo fertility preservation are invited to participate in a prospective study aiming at long-term follow-up after fertility preservation for oncologic and non-oncologic conditions.
Detailed description
In this study, the investigators aim at analyze the treatment outcomes of patients with infertility, their clinical characteristics and biochemical parameters aiming at identifying predictors for the treatment outcomes.
For the cohort of patients that have undergone fertility preservation at Karolinska University Hospital, the investigators aim at investigating efficacy and safety of the procedures.
The data can be expanded by using additional databases such as the Regional Cancer Registry and other registries.
Analysis of data collected will allow the investigation of efficacy and safety of fertility preservation, identification of predictors for fertility outcomes,prediction of future activities and costs of the procedures.
Interventions
- Procedure fertility preservation, several methods
fertility preservation using assisted reproductive techniques or not
Primary outcome measures
- Efficacy and safety of fertility preservation - Long-term follow-up [Time frame: 2028]
Secondary outcome measures (4)
- Clinical outcome of fertility treatments i breast cancer patients [Time frame: 5-20 years post diagnosis]
- Clinical outcome of fertility treatments i breast cancer patients [Time frame: 5-7 years post diagnosis]
- Predictors of effictive fertility treatment [Time frame: patient data collected from time of treatment, pregnancy rate until end of study]
- Efficacy and safety of COS using GnRHa for fertility preservation in BC patients [Time frame: Observed outcomes in patients registered between 1995 and 2017. Follow up until end of 2018.]
Eligibility criteria
Inclusion criteria
- infertile patients and patients who undergo fertility preservation
Exclusion criteria
- Healthy individuals, fertile population
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Sweden · 1 center
- Reproductive Medicine, Karolinska University Hospital — Stockholm
Publications
- Wikander I, Lundberg FE, Nilsson H, Borgstrom B, Rodriguez-Wallberg KA. A Prospective Study on Fertility Preservation in Prepubertal and Adolescent Girls Undergoing Hematological Stem Cell Transplantation. Front Oncol. 2021 Jun 30;11:692834. doi: 10.3389/fonc.2021.692834. eCollection 2021. PMID 34277437
Identifiers
NCT: NCT04602962 · KI-KRW-200909-201505