Peripartum Mental Health Cohort Study in Guangzhou
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Depression, Anxiety. Basic parameters: No limits · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this study is to determine the incidence,development trajectory and risk factors of the main peripartum mental health problems as well as explore its adverse outcomes.
Detailed description
Peripartum mental health problems (such as anxiety and depression), affecting more than 20% of mothers, is one of the most common complications around childbirth and gradually have become global public health issues. However, little is known about the course of peripartum mental health problems and possible fluctuations, as well as related risk factors among Chinese women. In addition, there are no effective prediction and preventive strategies for postpartum depression. The Peripartum Mental Health Cohort Study in Guangzhou will collect the epidemiological, clinical information and biological specimens across pregnancy and childbirth to establish trajectory of peripartum mental health and identify the factors influencing the fluctuations and build a comprehensive prediction model of postpartum depression, as well as explore its adverse outcomes. This study would help to determine the timing of screening and target interventions to improve women's and their offspring's health.
Primary outcome measures
- Change of prevalence of maternal prenatal depression [Time frame: before 20th gestational week, after 33th gestational week and prior to delivery]
- Change of prevalence of maternal postpartum depression in the first year after delivery [Time frame: 6 weeks, 6 months and 1 year after delivery]
Secondary outcome measures (5)
- Change of prevalence of maternal anxiety during pregnancy [Time frame: before 20th gestational week, after 33th gestational week and prior to delivery]
- Level of maternal cortisol during pregnancy [Time frame: During period of 2-3 trimesters of pregnancy]
- Levels of maternal inflammatory factors during pregnancy [Time frame: During period of 2-3 trimesters of pregnancy]
- Prevalence of preterm birth, small for gestational age, low birth weight [Time frame: At delivery]
- Child's neurodevelopment at early childhood [Time frame: At child's age of 1 year]
Eligibility criteria
Inclusion criteria
- Pregnant women with <20 weeks of gestation
- Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou with their child for more than 3 years
Exclusion criteria
- Combined with heart disease, hypertension, diabetes or hyperthyroidism
- Taking anti-depressants and other treatments for depression
- Participants was in infection status when the biological samples were collected
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Guangzhou Women and Children's Medical Center — Guangzhou
Publications
- Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. PMID 28321694
Identifiers
NCT: NCT04499066 · 2018053101