Assess the Risk of Cerebrovascular Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: GE Discovery MR750 3.0t superconducting MRI.
- Who it may be relevant to
- Registry conditions: Cerebrovascular Disease. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Head and Neck CTA Combined With Multimodal MRI to Assess the Risk of Cerebrovascular Disease
Overview
Intracranial artery stenosis is an important cause of ischemic stroke, but the degree of intracranial artery stenosis is not completely matched with the symptoms of ischemic stroke. Asymptomatic carotid stenosis (ACS) refers to does not appear related neurological symptoms of carotid stenosis and stroke or transient ischemic attack of carotid stenosis, did not happen cerebrovascular events such as stroke, but there have been a different degree of cognitive impairment, be badly in need of development of noninvasive imaging methods, objective evaluation of the ACS group cognitive impairment, and predict the ACS risk of ischemic stroke. Therefore, this topic proposed comprehensive cognitive assessment, CTA, double modal MRI techniques, clinical and biochemical indicator detection, mathematical modeling and statistical analysis techniques, assess the ACS group and normal person the cognitive ability, the difference of NVC and local perfusion, and follow-up ACS crowd of ischemic stroke and other cardiovascular events, discuss ACS and cognitive impairment, the correlation of NVC and local perfusion abnormalities, screening of radiographic predictor of ischemic stroke, and in the follow-up of ACS population in testing the sensitivity of the series of indicators and specific degrees.
Interventions
- Device GE Discovery MR750 3.0t superconducting MRI
T2WI, FLAIR, DWI, 3D BRAVO, 3D-ASL, rs-fMRI, DKI sequences to exclude other organic lesions
Primary outcome measures
- Dynamic change and correlation analysis of multi-dimensional features of ACS degree and cognitive impairment [Time frame: 2020.01]
Eligibility criteria
Inclusion criteria
- Mild stenosis group: CTA suggested carotid stenosis < 30%;
- Moderate stenosis group: CTA suggested carotid stenosis of 30-69%;
- Severe stenosis group: CTA indicated carotid stenosis ≥70%;
Exclusion criteria
- dementia, MMSE score < 21;
- previous carotid stenosis related neurological symptoms or transient ischemic attack;
- other craniocerebral lesions, such as craniocerebral trauma, tumor, inflammation, and complications of great vessels (cerebral infarction or cerebral malacia);
- contraindications for MRI examination;
- recent use of psychoactive drugs or hormones.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Wen Wang — Xi'an
Identifiers
NCT: NCT04443439 · 2018LCYJ005