Bioenergetic Phenotypes and Cardiometabolic Health
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: 8 years — 10 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Linking Bioenergetic Phenotypes in Circulating Cells with Cardiometabolic Health in School-age Children
Overview
This research study is about how daily activities, behaviors, and fitness affect the health and function of blood cells and their mitochondria, which are the powerhouses of the cells. These small mitochondria inside the cells make energy, and are very important for the health of the body.
Detailed description
Determine the impact of physical activity and obesity status on circulating cells mitochondrial function (e.g., fat vs. carbohydrates combustion capacity, total oxidative capacity, mitochondrial number and proton leak).
Primary outcome measures
- Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old. [Time frame: 8 days]
Eligibility criteria
Inclusion criteria
Ages 8-10 years Boys and girls All ethnicity All BMI
Exclusion criteria
severe persistent asthma exercise induced asthma autism spectrum disorder attention deficit hyperactivity disorder attention deficit disorder
- Opposition defiant disorder
- conduct disorder
- epilepsy
- chronic kidney disease
- hormonal disease
- autoimmune diseases
- bleeding disorders
- chronic infections
- mental health disorder
- Type 2 and Type 1 diabetes
- Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Arkansas Children's Nutrition Center — Little Rock
Identifiers
NCT: NCT04427462 · 260376