Non-invasive Evaluation Program for TIPS and Follow Up Network 2 (NEPTUN2)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: TIPS procedure.
- Who it may be relevant to
- Registry conditions: Portal Hypertension. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Germany
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Non-invasive Evaluation of Prognostic Parameters for Patients With Transjugular Intrahepatic Portosystemic Shunt (TIPS) Using a Structured Follow up Protocol 2
Overview
Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.
Detailed description
NEPTUN consists of liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and/or biopsy criteria.
Interventions
- Device TIPS procedure
Implantation of TIPS for portal hypertension
Primary outcome measures
- Survival [Time frame: up to 10 years]
Secondary outcome measures (9)
- Ascites [Time frame: up to 10 years]
- Hepatic Encephalopathy (HE) [Time frame: up to 10 years]
- Variceal Bleeding [Time frame: up to 10 years]
- Liver Failure [Time frame: up to 10 years]
- Acute-on-Chronic Liver Failure (ACLF) [Time frame: up to 10 years]
- Organ Failures [Time frame: up to 10 years]
- Kidney Failure [Time frame: up to 10 years]
- Sarcopenia [Time frame: up to 10 years]
- post-surgical survival [Time frame: up to 10 years]
Eligibility criteria
Inclusion criteria
- Insertion of TIPS according to guidelines
Exclusion criteria
- Contraindication for TIPS
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Germany · 1 center
- University Hospital Bonn — Bonn
Publications
- Heger LA, Chang J, Rohrer C, Reincke M, Eyth A, Sturm L, Schultheiss M, Maier A, Meyer C, Jansen C, Graf K, Ozturk C, Schneider F, Trebicka J, Westermann D, Thimme R, Grundmann S, Praktiknjo M, Bettinger D. Right Ventricular Contractility Predicts Clearance of Ascites After Transjugular Intrahepatic Portosystemic Shunt. Liver Int. 2025 Dec;45(12):e70422. doi: 10.1111/liv.70422. PMID 41204773
Identifiers
NCT: NCT04393519 · NEPTUN2