Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Observation.
- Who it may be relevant to
- Registry conditions: Cardiovascular Diseases, Cardiovascular Risk Factor. Basic parameters: 18 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This project will examine the diagnosis and prognosis of patients with cardiovascular disease in hospital in- and outpatients and compare their characteristics with normal controls from the community. The cardiovascular diseases studied include coronary artery disease, heart failure, heart attacks, valve disease, cardiac surgery, dysrhythmias, aneurysms, embolism, strokes, peripheral vascular disease and hypertension. Current methods for diagnosis and predicting outcome in patients are limited and may lack accuracy. This study will collect clinical details, and blood and urine samples from patients for analysis of proteins, chemicals and genetic biomarkers which will enable an examination of the pathological mechanisms involved in cardiovascular disease. The data will also be used to improve diagnosis and also improve prediction of outcome in patients (future clinical events such as death, further hospitalisation with cardiovascular disease and the effects of any therapy given to the patients). In this way, we can develop accurate ways of assessing a patient's condition and how it could be effectively managed. The study will last for 20 years.
Interventions
- Other Observation
Physiological Measurements Patient reported questionnaire Blood sampling
Primary outcome measures
- To improve understanding of disease mechanisms in cardiovascular disease [Time frame: 20 Years]
Secondary outcome measures (1)
- To improve prediction of responses to different treatments, using blood proteins or chemicals and a patient's genetic makeup [Time frame: 20 Years]
Eligibility criteria
Inclusion criteria
- All outpatients and inpatients with cardiovascular disease, of either gender
- Aged 18-90 years old
- Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain
- Healthy volunteers
- Aged 18-90 years old
- From the community without cardiovascular or other diseases
Exclusion criteria
- Any patient who is unable to give consent
- Any patient with non-cardiovascular comorbidity likely to cause death within 6 months
- Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United Kingdom · 1 center
- University Hospitals Leicester — Leicester
Identifiers
NCT: NCT04388943 · 14022