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Recruiting NCT04361994

The GErman Italian Spanish Takotsubo (GEIST) Registry

— Observational Takotsubo Syndrome

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Takotsubo Syndrome. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Germany, Italy
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

GEIST is a multicenter, international observational registry of patients with Takotsubo syndrome. Data regarding the clinical profile (demographic characteristics, clinical presentation, laboratory measures, electrocardiography /echocardiography / coronary angiography parameters, treatment and medication), in-hospital course and complications and short-/long-term outcome are collected prospectively and retrospectively to increase the understanding of the disease.

Detailed description

The open-ended, multicenter, international GEIST registry collects data from patients with Takotsubo syndrome during the index hospitalization and follow-up. Furthermore, long-term outcome data are acquired with structured telephone interviews, in case patients do not undergo regular outpatient visits in the participating study centers. The GEIST registry retrospectively includes data, which have already been collected, and prospectively continues to enroll patients with newly diagnosed Takotsubo syndrome.

Primary outcome measures

  • All-cause mortality [Time frame: Day 0]
  • All-cause mortality [Time frame: 3 Month]
  • All-cause mortality [Time frame: 6 Month]
Secondary outcome measures (1)
  • In-Hospital complications [Time frame: Day 0]

Eligibility criteria

Inclusion criteria

  • Patients with Takotsubo syndrome

Exclusion criteria

  • Non

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Germany · 1 center
  • Universität zu Lübeck — Lübeck
Italy · 1 center
  • University of Foggia — Foggia

Publications

  • Raposeiras-Roubin S, Santoro F, Arcari L, Vazirani R, Novo G, Uribarri A, Enrica M, Lopez-Pais J, Guerra F, Alfonso F, Patz T, Fernandez-Cordon C, Montisci R, Corbi-Pascual M, Marchetti MF, Almendro M, Cacciotti L, Vedia O, El-Battrawy I, Blanco-Ponce E, Brunetti ND, Akin I, Martinez-Selles M, Thiele H, Stiermaier T, Eitel I, Nunez-Gil IJ; GEIST Researchers. Beta-Blockers and Long-Term Mortality i PMID 39918532
  • Santoro F, Stiermaier T, Nunez Gil IJ, El-Battrawy I, Patz T, Cacciotti L, Guerra F, Novo G, Musumeci B, Volpe M, Mariano E, Caldarola P, Montisci R, Ragnatela I, Cetera R, Vazirani R, Lluch C, Uribarri A, Corbi-Pascual M, Conty Cardona DA, Akin I, Barbato E, Thiele H, Brunetti ND, Eitel I, Arcari L. Renin angiotensin system inhibitors and outcome in patients with takotsubo syndrome: A propensity PMID 39260785
  • El-Battrawy I, Santoro F, Nunez-Gil IJ, Patz T, Arcari L, Abumayyaleh M, Guerra F, Novo G, Musumeci B, Cacciotti L, Mariano E, Caldarola P, Parisi G, Montisci R, Vitale E, Volpe M, Corbi-Pasqual M, Martinez-Selles M, Almendro-Delia M, Sionis A, Uribarri A, Thiele H, Brunetti ND, Eitel I, Akin I, Stiermaier T. Age-Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registr PMID 38348805
  • Stiermaier T, Walliser A, El-Battrawy I, Patz T, Mezger M, Rawish E, Andres M, Almendro-Delia M, Martinez-Selles M, Uribarri A, Perez-Castellanos A, Guerra F, Novo G, Mariano E, Musumeci MB, Arcari L, Cacciotti L, Montisci R, Akin I, Thiele H, Brunetti ND, Nunez-Gil IJ, Santoro F, Eitel I. Happy Heart Syndrome: Frequency, Characteristics, and Outcome of Takotsubo Syndrome Triggered by Positive Lif PMID 35772855
  • El-Battrawy I, Santoro F, Stiermaier T, Moller C, Guastafierro F, Novo G, Novo S, Mariano E, Romeo F, Romeo F, Thiele H, Guerra F, Capucci A, Giannini I, Brunetti ND, Eitel I, Akin I. Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular Ballooning) in Takotsubo Syndrome: Results From the GEIST Registry. Chest. 2021 Oct;160(4):1433-1441. doi: 10.1016/j.chest.2021.04.072. Ep PMID 34052189

Identifiers

NCT: NCT04361994 · 00

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗