Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors.
- Who it may be relevant to
- Registry conditions: Cryptorchidism. Basic parameters: 1 months — 18 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.
Detailed description
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.
Interventions
- Other Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors
Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)
Primary outcome measures
- frequency of the job exposure of the parents of endocrine disruptors [Time frame: 1 day]
Secondary outcome measures (4)
- comparison of cryptorchid and non-cryptorchid children born to parents with isolated exposure vs multiple exposures [Time frame: 1 day]
- Comparison of frequencies of exposure to endocrine disruptors (Environmental Disrupting Chemicals) in parents giving birth to a congenital cryptorchid child vs child not cryptorchid at birth but with secondary cryptorchidism. [Time frame: 1 day]
- identify food exposure criteria (phytoestrogen or EDC pesticides) associated with the presence of a cryptorchid. [Time frame: 1 day]
- Constitution of collection of biological samples from children with non-palpable bilateral cryptorchidism [Time frame: 1 day]
Eligibility criteria
Inclusion criteria
\- Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism
Exclusion criteria
- Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.)
- Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities)
- Testicular Ectopia (testis outside of normal migration path)
- Anorchidism and evanescent testicles, united or bilateral
- Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)
- Cryptorchidism integrating in the context of a polymalformative syndrome, including neurological.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
France · 1 center
- University hospital of Montpellier — Montpellier
Identifiers
NCT: NCT04342026 · RECHMPL19_0544