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Recruiting NCT04310098

CADASIL Registry Study

— Observational Cadasil

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Cadasil. Basic parameters: 18 years — 85 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study

Overview

The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.

Primary outcome measures

  • Overall outcomes in CADASIL patients [Time frame: From date of enrollment until the date of death from any cause, assessed up to 20years]
Secondary outcome measures (1)
  • The correlation of genotype and phenotype [Time frame: From date of enrollment until the date of death from any cause, assessed up to 20years]

Eligibility criteria

Inclusion criteria

  • Sign informed consent.
  • Age>18
  • Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy
  • Asymptomatic NOTCH3 mutation carriers
  • Relatives of CADASIL patients or carriers
  • Unrelated healthy controls

Exclusion criteria

  • Unable to cooperate with inspectors
  • Serious systemic illness, such as heart, liver, kidney disease or major mental illness
  • Contraindications for imaging examination

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

China · 1 center
  • Department of Neurology , First Affiliated Hospital Fujian Medical University — Fuzhou

Identifiers

NCT: NCT04310098 · MRCTA,ECFAH of FMU [2019]244-1

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗