Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Transcranial Direct Current Stimulation.
- Who it may be relevant to
- Registry conditions: Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
Detailed description
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.
Interventions
- Device Transcranial Direct Current Stimulation
In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes.
Primary outcome measures
- Change in N-Back Task [Time frame: Baseline to Post-Treatment, 1 Week]
Secondary outcome measures (5)
- Change in Flanker Task [Time frame: Baseline to Post-Treatment, 1 Week]
- Change in Multi-Source Interference with International Affective Picture System Task [Time frame: Baseline to Post-Treatment, 1 Week]
- Change in Delayed Discounting Task [Time frame: Baseline to Post-Treatment, 1 Week]
- Change in Stop Signal Task [Time frame: Baseline to Post-Treatment, 1 Week]
- Change in Iowa Gambling Task [Time frame: Baseline to Post-Treatment, 1 Week]
Eligibility criteria
Inclusion criteria
- Male and female outpatients 18-65 years of age
- A diagnosis of traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
Exclusion criteria
- Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy.
- Active substance dependence (except for tobacco and cannabis).
- Pregnant or nursing females.
- Inability to participate in testing procedures.
- Additional exclusion criteria for healthy controls:
- Diagnosis of psychiatric of neurological disorder
- Ongoing treatment with any psychotropic medications.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Massachusetts General Hospital — Boston
Identifiers
NCT: NCT04296604 · 2014P001428