Cortical-Basal Ganglia Speech Networks
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: electrophysiological data collection.
- Who it may be relevant to
- Registry conditions: Parkinson Disease, Essential Tremor, Dystonia. Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
In this research study the researchers want to learn more about brain activity related to speech perception and production.
Detailed description
Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.
Interventions
- Other electrophysiological data collection
Electrophysiological data collection at the time of DBS surgery.
Primary outcome measures
- The number of subjects providing the interpretable speech related electrophysiological data collection. [Time frame: Duration of single DBS surgery]
Eligibility criteria
Inclusion criteria
- Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
- Subjects able to provide informed consent and comply with task instructions.
- Subjects 18-85 years old
Exclusion criteria
- Subjects with reported hearing loss.
- Non-English-speaking subjects
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Massachusetts General Hospital — Boston
Identifiers
NCT: NCT04286308 · 2019P003841