The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: The Inspire Bio-resource Research Platform for Healthy Aging.
- Who it may be relevant to
- Registry conditions: Biological Aging. Basic parameters: from 30 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Inspire Bio-resource Research Platform for Healthy Aging
Overview
Since aging is a systemic (not organ-specific) phenomenon, the main objective of Inspire Bio-resource Research Platform for Healthy Aging is to build a comprehensive research platform gathering biological, clinical (including imaging) and digital resources that will be explored to identify robust (set of) markers of aging, age-related diseases and IC evolution. The Inspire Platform will gather data and biospecimens from subjects of different ages (from 30 years or over - no upper limit for age) and functional capacity levels (from robust to frail to disabled) over 10 years.
Detailed description
This is a 10-year observational study. The study will be performed in Occitania Region. Once a year, a complete data collection will be performed in the Gerontopole of Toulouse, in participants' home and health centers by the Gerontopole mobile research team, and in selected Gerontopole's collaborating centers in Occitania.
Between yearly waves of data collection, participants will have their intrinsic capacity domains monitored (with or without the help of a caregiver) each 4-month through the use of either an app developed in collaboration with World Health Organization (WHO) or a web platform; or through a phone call by a clinical/research nurse. For the first self-monitoring of IC at four months, all participants will be contacted by a research/clinical nurse by phone; this call will inform about how participants measured their capacity and/or help them to do it. After this first 4-month phone call, participants capable of correctly self-monitoring their IC through the app will no longer be systematically contacted by phone. Once IC declines are confirmed, participants will have a thorough clinical assessment and blood sampling; such information will allow us to investigate the response of markers of aging at the time declines are detected. Those needing usual care, will be followed according to WHO framework recommendations proposed for Integrated Care for Older Adults (ICOPE).
Interventions
- Other The Inspire Bio-resource Research Platform for Healthy Aging
Several follow-up visits will be undertaken during the 10-year time frame of this project. Some of these visits are not regularly scheduled and will be conditioned by the remote monitoring of intrinsic capacity (IC) and the onset of other major clinical conditions. Other visits correspond to the regularly scheduled (yearly or every two years (biannual visits), depending on the outcome measures) waves of data collection.
Primary outcome measures
- Data collection of key variables and biospecimens [Time frame: through study completion, an average of 10 years]
Secondary outcome measures (12)
- Identification of (a set of) biomarkers of aging through the constitution of a comprehensive biobank comprising: blood, saliva, urine, nasopharyngeal swabbing, skin biopsies and surface samples, dental plaque, faeces, hair bulb. [Time frame: through study completion, an average of 10 years]
- measure intrinsic capacity domains with questionnaire in ICOPE App (developed in collaboration with W.H.O.) [Time frame: through study completion, an average of 10 years]
- Basic and instrumental activities of daily living. [Time frame: through study completion, an average of 10 years]
- Mini-nutritional assessment and food frequency questionnaire. [Time frame: through study completion, an average of 10 years]
- Lifestyle questionnaires [Time frame: through study completion, an average of 10 years]
- ActivPAL: objectively physical activity parameters. [Time frame: through study completion, an average of 10 years]
- Self-reported visceral pain. [Time frame: through study completion, an average of 10 years]
- Participant-reported outcome for cognition (CFI) [Time frame: through study completion, an average of 10 years]
- Participant-reported outcome for mobility [Time frame: through study completion, an average of 10 years]
- Participant-reported outcome for fatigue [Time frame: through study completion, an average of 10 years]
- Participant-reported outcome for social isolation (PROMIS) [Time frame: through study completion, an average of 10 years]
- Participant-reported outcome for SARQoL. [Time frame: through study completion, an average of 10 years]
Eligibility criteria
Inclusion criteria
- Aged 30 years-old or over;
- Both sexes
- Affiliated to a social security scheme
Exclusion criteria
- severe disease compromising life expectancy at 5 years;
- Deprived of their liberty by administrative or judicial decision, or under guardianship
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- University Hospital Toulouse — Toulouse
Publications
- Cabrol A, Shourick J, Coley N, Oustric S, Guyonnet S, Vellas B, Escourrou E, Andrieu S; IHU HealthAge INSPIRE/Open Science study group. Feeling Younger as an Indicator of Better Overall Intrinsic Capacities in the INSPIRE-T Cohort. Int J Geriatr Psychiatry. 2026 May;41(5):e70220. doi: 10.1002/gps.70220. PMID 42059106
- Bellelli F, Raffin J, Cesari M, Guyonnet S, Furman D, Rolland Y, Vellas B, de Souto Barreto P; IHU HealthAge INSPIRE Platform Group; IHU HealthAge Open Science group. The association of pain with intrinsic capacity and the moderating role of inflammation in France: a cross-sectional analysis of the INSPIRE-T project. Lancet Healthy Longev. 2025 Dec;6(12):100798. doi: 10.1016/j.lanhl.2025.100798. E PMID 41360071
Identifiers
NCT: NCT04224038 · RC31/19/0236