Donor Outcomes Following Hand-Assisted and Robotic Living Donor Nephrectomy: a Retrospective Review
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: kidney transplant.
- Who it may be relevant to
- Registry conditions: Transplant, Kidney Diseases. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
1.1. Background: Renal transplantation is the treatment of choice for eligible patients with end-stage renal disease. It provides better outcomes in terms of life expectancy and quality of life than dialysis (Liu, Narins, Maley, Frank, \& Lallas, 2012). Kidney transplants from living donors also have additional benefits in terms of graft function and survival compared to transplants from cadaver donors (Galvani et al., 2012). Living donor transplants provide an opportunity to have good quality grafts and to perform the procedure when the recipient is in an optimal clinical status (Creta et al., 2019). Laparoscopic donor nephrectomy was first introduced in 1995 and is currently accepted as the gold standard for kidney procurement from living donors. The first worldwide robotic assisted laparoscopic donor nephrectomy was performed in 2000 by Horgan et al. (Horgan et al., 2007). The main obstacle to living donation is the exposure of a healthy subject to the risks of a major surgical intervention. Therefore, efforts have been made to reduce complications and postoperative pain, achieve faster recovery, and minimize the surgical incisions. Minimally invasive procedures like hand-assisted and robotic approaches greatly enhance living donation rates, and in 2001 the number of living donors exceeded the number of cadaver donors (Horgan et al., 2007). 1.2. Aim(s)/Objective(s): The objective of this study is to compare intra- and postoperative patient outcomes of kidney donors following hand-assisted and robotic kidney transplants at a single center. 1.3. Rationale for the study: More research is needed regarding the differences between minimally invasive approaches to kidney transplantation.
Detailed description
This is a retrospective, single-center cohort study. Clinical data will be collected from electronic medical records (EMRs) on donors and recipients who underwent a minimally invasive kidney transplantation procedure. Data from all patients who had a hand-assisted or robotic minimally invasive kidney transplantation procedure at Methodist Dallas Medical Center (MDMC) between January 2006 and November 2019 will be included in the study.
Interventions
- Procedure kidney transplant
Clinical data will be collected from electronic medical records (EMRs) on donors and recipients who underwent a minimally invasive kidney transplantation procedure
Primary outcome measures
- Patient demographics [Time frame: between January 2006 and November 2019]
- Kidney Laterality [Time frame: between January 2006 and November 2019]
- operating room (OR) time (minutes) [Time frame: between January 2006 and November 2019]
- warm ischemia time (minutes) [Time frame: between January 2006 and November 2019]
- estimated blood loss (EBL) (milliliters (mL)) [Time frame: between January 2006 and November 2019]
- complications (using Clavien-Dindo scale) [Time frame: between January 2006 and November 2019]
- hospital length of stay (LOS) (days from admit to discharge) [Time frame: between January 2006 and November 2019]
- 30-day readmissions [Time frame: between January 2006 and November 2019]
- BMI (kilogram per square meter (kg/m^2)) [Time frame: between January 2006 and November 2019]
- hospital-based charges/costs [Time frame: between January 2006 and November 2019]
Eligibility criteria
Inclusion criteria
- ≥ 18 years of age
- Kidney donors and recipients who underwent a hand-assisted or robotic kidney transplant
Exclusion criteria
- Patients that do not meet the Study Inclusion Criteria laid out above
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- The Liver Institute at Methodist Dallas Medical Center — Dallas
Identifiers
NCT: NCT04182607 · 063.HPB.2019.D