Registry Study on "Control Nocturnal Hypertension to Reach the Target "
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Nocturnal Hypertension. Basic parameters: 50 years — 79 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Registry Study on "Control Nocturnal Hypertension to Reach the Target "（CONTROL-NHT）
Overview
Ambulatory blood pressure monitoring (ABPM) is a major innovation in the history of hypertension diagnosis. In clinical practice, the most well established indication for using ABPM is to identify patients who have high BP readings in the office but normal readings during usual daily activities outside of this setting or vice versa, and to identify varying 24-h BP profiles. However, in recent years, there has been increasing interest in BP values during sleep, and nocturnal BP is now recognized to be superior to daytime BP in predicting fatal and nonfatal cardiovascular events (stroke, myocardial infarction, and cardiovascular death), especially in medicated patients. The current direction in the management of hypertension is toward earlier and lower BP control for 24 hours, including the nocturnal and morning periods. Therefore, it may be of great significance to pay attention to the management of nocturnal blood pressure so as to reduce the increased cardiovascular risks. Information of nocturnal hypertensive patients defined by ABPM was prospectively registered nationwide, and then to investigate whether there was difference in cardiovascular prognosis according to the control of ambulatory nocturnal blood pressure.
Primary outcome measures
- The occurrence time of fatal and non-fatal cardiovascular events. [Time frame: From date of enrollment until date of first documented event assessed up to 3 years]
Secondary outcome measures (2)
- The occurrence time of all-cause mortality. [Time frame: From date of enrollment until date of first documented event, assessed up to 3 years]
- The occurrence time of fatal and nonfatal stroke. [Time frame: From date of enrollment until date of first documented event assessed up to 3 years]
Eligibility criteria
Inclusion criteria
- Age 50-79 years old
- Clinical diagnosed hypertension with the use of antihypertensive drugs
- Nocturnal hypertension ( nocturnal systolic blood pressure ≥ 130 mmHg and/or nocturnal diastolic blood pressure ≥ 80 mmHg)
- A 24-hour ambulatory blood pressure monitoring was performed with validated equipment.
- Willing to provide information about disease history and blood biochemical test data within 6 months.
- Sign the informed consent
Exclusion criteria
- Without antihypertensive drug use
- Hospitalized hypertension patients
- Non-compliant patient
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Ruijin Hospital — Shanghai
Identifiers
NCT: NCT04137549 · CONTROL-NHT