Obstructive Sleep Apnea Among Somali-Americans
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Obstructive Sleep Apnea. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Evaluating the Prevalence and Implications of Obstructive Sleep Apnea Among Somali-Americans: A Translational Research Study
Overview
The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.
Detailed description
Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.
Primary outcome measures
- To assess the prevalence of obstructive sleep apnea [Time frame: 10 years]
- To determine the severity of obstructive sleep apnea [Time frame: 10 years]
Secondary outcome measures (4)
- 24 hour mean arterial pressure [Time frame: 10 years]
- Vascular endothelial function [Time frame: 10 years]
- Insulin sensitivity [Time frame: 10 years]
- Body composition [Time frame: 10 years]
Eligibility criteria
Inclusion criteria
- Self-identify as Somali, African, Asian, and European descent.
- Adult males and females who are older than 18 years of age.
Exclusion criteria
- Minors under 18 years or adults over 100 years
- Positive pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Mayo Clinic — Rochester
Publications
- Greenlund IM, Bock JM, Govindan N, Kantas D, Singh P, Covassin N, Somers VK. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans. J Racial Ethn Health Disparities. 2026 Jun;13(3):1961-1966. doi: 10.1007/s40615-025-02389-7. Epub 2025 Mar 15. PMID 40088388
- Greenlund I, Bock J, Govindan N, Kantas D, Singh P, Covassin N, Somers V. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans. Res Sq [Preprint]. 2024 Oct 21:rs.3.rs-4925722. doi: 10.21203/rs.3.rs-4925722/v1. PMID 39502777
- Greenlund IM, Kantas D, Prakash SS, Bock JM, Covassin N, Somers VK. Nocturnal Hemodynamics in Somali Americans: Implications for Cardiovascular Risk. Am J Nephrol. 2024;55(6):629-637. doi: 10.1159/000540987. Epub 2024 Aug 24. PMID 39182475
Identifiers
NCT: NCT04124848 · 19-000033