Recruiting NCT04113356
Magnetic Resonance Imaging In Acute ST-Elevation Myocardial Infarction
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cardiovascular Magnetic Resonance Imaging.
- Who it may be relevant to
- Registry conditions: Acute ST-Elevation Myocardial Infarction. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Austria
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Clinical Relevance of Magnetic Resonance Imaging in Acute ST-Elevation Myocardial Infarction
Overview
Cardiovascular magnetic resonance imaging enables comprehensive assessment of cardiovascular function, morphology and pathology. The investigators aim to evaluate the nature and clinical significance of magnetic resonance imaging parameters in patients presenting with first acute ST-elevation myocardial infarction.
Interventions
- Diagnostic test Cardiovascular Magnetic Resonance Imaging
Cardiovascular magnetic resonance imaging will be performed within the first week after ST-elevation myocardial infarction and in a defined subgroup 4 months, 12 months and 10 years thereafter.
Primary outcome measures
- Occurence of major adverse cardiovascular events [Time frame: 1 - 5 years]
Secondary outcome measures (12)
- Infarct size assessment (% of left ventricular myocardial mass) [Time frame: baseline, 4 months and 12 months]
- Assessment of infarct transmurality grade (%) with late gadolinium enhancement imaging [Time frame: baseline, 4 months and 12 months]
- Occurence and area of microvascular obstruction [Time frame: baseline]
- Intramyocardial haemorrhage assessed by T2* imaging [Time frame: baseline, 4 months and 12 months]
- Tissue characterisation by T1, T2 and T2* Mapping [Time frame: baseline, 4 months and 12 months]
- Myocardial deformation by strain analysis [Time frame: baseline, 4 months and 12 months]
- Chamber volumes by cine imaging [Time frame: baseline, 4 months and 12 months]
- Cardiac function by cine imaging [Time frame: baseline, 4 months and 12 months]
- Stroke volumes by phase contrast imaging [Time frame: baseline, 4 months and 12 months]
- Aortic pulse wave velocity and distensibility by phase contrast imaging [Time frame: baseline, 4 months and 12 months]
- Aortic pulse wave distensibility by phase contrast imaging [Time frame: baseline, 4 months and 12 months]
- Quality of life and invalidity assessment (Global Physical Activity Questionnaire) [Time frame: 1 - 5 years]
Eligibility criteria
Inclusion criteria
- First ST-elevation myocardial infarction according to the European Society of Cardiology/American College of Cardiology committee criteria
- Primary percutaneous coronary intervention within 24 hours after symptom onset
Exclusion criteria
- Age < 18 years
- Any history of a previous myocardial infarction or coronary intervention
- Clinically unstable patients (Killip class >2)
- Renal failure (estimated glomerular filtration rate < 30 ml/min/1.73 m2)
- Contraindications to cardiac magnetic resonance imaging (pacemaker, cerebral aneurysm clip, orbital foreign body, known or suggested contrast allergy to gadolinium, claustrophobia)
- Inability to provide informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Austria · 2 centers
- University Hospital for Internal Medicine III (Cardiology and Angiology) — Innsbruck
- University Hospital for Radiology — Innsbruck
Publications
- Schwab M, Pamminger M, Kremser C, Almar-Munoz E, Reinstadler SJ, Reindl M, Metzler B, Haltmeier M, Mayr A. Association of Deep Learning-based Myocardial Infarction Size Quantification in Cardiac MRI with Cardiac Biomarker Levels. Radiol Cardiothorac Imaging. 2026 Jun;8(3):e250235. doi: 10.1148/ryct.250235. PMID 42347575
- Lechner I, Reindl M, von der Emde S, Desheva A, Oberhollenzer F, Tiller C, Holzknecht M, Kremser T, Faccini J, Gollmann-Tepekoylu C, Kremser C, Mayr A, Bauer A, Metzler B, Reinstadler SJ. Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications. Circ Cardiovasc Imaging. 2024 Dec;17(12):e017041. doi: 10.1161/CIRCIMAGING.124.017041. Epub 2024 Nov 29. PMID 39611252
- Tiller C, Holzknecht M, Lechner I, Oberhollenzer F, von der Emde S, Kremser T, Gollmann-Tepekoylu C, Mayr A, Bauer A, Metzler B, Reinstadler SJ, Reindl M. Association of Circulating PCSK9 With Ischemia-Reperfusion Injury in Acute ST-Elevation Myocardial Infarction. Circ Cardiovasc Imaging. 2024 Aug;17(8):e016482. doi: 10.1161/CIRCIMAGING.123.016482. Epub 2024 Aug 20. PMID 39163371
- Holzknecht M, Tiller C, Reindl M, Lechner I, Fink P, Lunger P, Mayr A, Henninger B, Brenner C, Klug G, Bauer A, Metzler B, Reinstadler SJ. Association of C-Reactive Protein Velocity with Early Left Ventricular Dysfunction in Patients with First ST-Elevation Myocardial Infarction. J Clin Med. 2021 Nov 24;10(23):5494. doi: 10.3390/jcm10235494. PMID 34884196
- Tiller C, Reindl M, Holzknecht M, Lechner I, Schwaiger J, Brenner C, Mayr A, Klug G, Bauer A, Metzler B, Reinstadler SJ. Association of plasma interleukin-6 with infarct size, reperfusion injury, and adverse remodelling after ST-elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2022 Feb 8;11(2):113-123. doi: 10.1093/ehjacc/zuab110. PMID 34849677
- Lechner I, Reindl M, Tiller C, Holzknecht M, Niederreiter S, Mayr A, Klug G, Brenner C, Bauer A, Metzler B, Reinstadler SJ. Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction. Int J Cardiovasc Imaging. 2022 Jan;38(1):237-247. doi: 10.1007/s10554-021-02383-0. Epub 2021 Sep 2. PMID 34476665
- Reindl M, Lechner I, Tiller C, Holzknecht M, Rangger A, Mayr A, Theurl M, Klug G, Brenner C, Bauer A, Metzler B, Reinstadler SJ. Glycemic Status and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Imaging. 2021 Sep;14(9):1875-1877. doi: 10.1016/j.jcmg.2021.04.007. Epub 2021 May 19. No abstract available. PMID 34023265
- Reindl M, Tiller C, Holzknecht M, Lechner I, Eisner D, Riepl L, Pamminger M, Henninger B, Mayr A, Schwaiger JP, Klug G, Bauer A, Metzler B, Reinstadler SJ. Global longitudinal strain by feature tracking for optimized prediction of adverse remodeling after ST-elevation myocardial infarction. Clin Res Cardiol. 2021 Jan;110(1):61-71. doi: 10.1007/s00392-020-01649-2. Epub 2020 Apr 15. PMID 32296969
Identifiers
NCT: NCT04113356 · AN3775