Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Radical Image-Guided Radiotherapy.
- Who it may be relevant to
- Registry conditions: Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Hamlet-RT: Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy
Overview
The Hamlet.rt study is a prospective data collection and patient questionnaire study for patients undergoing image-guided radiotherapy with curative intent. The aim of the study is to use novel machine learning and mathematical techniques to build a model that can predict the risk of significant side effects from radiotherapy treatment for an individual patient: using calculations of normal tissue dose from radiotherapy treatment planning and patient baseline characteristics derived from image and non-image data, continuously updated as the patient is reviewed both during and after treatment. A secondary goal of the project is to facilitate research in machine learning and medical image processing for radiation therapy through the creation of a discoverable and shared data resource for research use.
Interventions
- Radiation Radical Image-Guided Radiotherapy
Questionnaires administered will monitor the clinical toxicity experienced by each patient up to 5 years post radiotherapy
Primary outcome measures
- Machine Learning Modelling [Time frame: 8 years from FPFV]
- Predictive Modelling [Time frame: 8 years from FPFV]
- Clinical Toxicity Evaluation [Time frame: 8 years from FPFV]
Eligibility criteria
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the study
- Male or Female
- Aged 18 years or older
- Diagnosed with primary prostate cancer, head and neck cancer, lung cancer, or brain tumour
- Treated with curative intent
- Suitable for radical image guided radiotherapy
- WHO ECOG performance status 0 or 1
- Expected survival of 18 months or more
Exclusion criteria
- Participant is not willing or able to complete the protocol-stated requirements of the study, e.g. accessing \& completing web-based long-term follow-up questionnaires.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 1 center
- Cambridge University Hospitals NHS Foundation Trust — Cambridge
Identifiers
NCT: NCT04060706 · Hamlet.rt