The Link Between Periodontitis, Smoking and Oral Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: biopsy for oral cancer, periodontal examination.
- Who it may be relevant to
- Registry conditions: Chronic Periodontitis, Oral Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Analysis of the Link Between Periodontitis, Smoking and Oral Cancer: Cohort Study
Overview
Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly. Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm. Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.
Interventions
- Diagnostic test biopsy for oral cancer
surgical biopsy is to be taken for diagnosis of oral cancer or premalignant lesions - Diagnostic test periodontal examination
Periodontal clinical examination to all by periodontal charting
Primary outcome measures
- Periodontitis [Time frame: the 10 years of the study]
Secondary outcome measures (1)
- Oral cancer [Time frame: the 10 years of the study]
Eligibility criteria
Inclusion criteria
- Patients 18 years or older.
Exclusion criteria
- Patients with any systemic diseases.
- Pregnant females.
- Handicapped and mentally retarded patients.
- Patients undergoing radiotherapy.
- Patients having oral cancer
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Cairo University — Cairo
Identifiers
NCT: NCT04047212 · P12