A Registered Cohort Study on Brain Calcification
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Brain Calcification. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Brain calcification is a common neuroimaging feature in patients with metabolic, neurological, or developmental disorders, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. To understand the clinical and genetic characteristics of brain calcification, we establish a cohort of brain calcification to follow up patients with brain calcification.
Primary outcome measures
- The incidence of hereditary brain calcification [Time frame: Up to 20 years]
Eligibility criteria
Inclusion criteria
- Patients with brain calcium deposit(s) based on examinations of CT scans
- Patients with total calcification score(TCS) greater than the physiological threshold
- Relatives of brain calcification patients.
- Unrelated healthy controls
- Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process
Exclusion criteria
- Brain calcification caused by specific secondary factors such as infection, poisoning, and trauma
- Participants declining or unable to comply with trial procedures and visit schedule
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Department of Neurology, First Affiliated Hospital Fujian Medical University — Fuzhou
Identifiers
NCT: NCT04010201 · MRCTA,ECFAH of FMU [2019]198