OSA and CV Outcomes in Patients With High Risk AF
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Overnight sleep study.
- Who it may be relevant to
- Registry conditions: Atrial Fibrillation, Obstructive Sleep Apnea. Basic parameters: 22 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Singapore
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective Study on Obstructive Sleep Apnea and Cardiovascular Outcomes in Patients With Atrial Fibrillation and High Cardiovascular Risk
Overview
The POACH study is part of the Cardiosleep research program. It is a prospective, observational, multicentre study conducted in Singapore. The recruitment target is 1365 patients. Eligible patients with AF and high cardiovascular risk will be recruited for a home-based sleep study using a FDA-approved portable device. The patients will be divided into 2 groups based on the presence or absence of OSA using apnoea-hypopnoea index ≥ 15 events/hour. The AF will be treated as per local standard practice. Participation in the POACH study will not affect the management of AF. Follow-up will be conducted every 6 months until the median follow-up duration has reached 2 years. The primary endpoint is a four-component composite of all-cause mortality, myocardial infarction, stroke and heart failure hospitalisation. Antecubital venous blood samples will be taken from the patients in the morning after the sleep study for targeted mass spectrometry which will measure 83 circulating metabolites. Sparse Principal Component Analysis will be used for data reduction. Identification of distinct associations between metabolic perturbations and OSA will be performed.
Detailed description
The overarching objective of the POACH study is to determine the impact of obstructive sleep apnoea (OSA) on cardiovascular outcomes in patients with atrial fibrillation (AF).
AF is the most prevalent sustained arrhythmia. While OSA often co-exists with AF, current management of AF does not take OSA status into consideration. This is partly due to the lack of data on whether OSA is independently associated with cardiovascular events in patients with AF. Besides, metabolomics is an emerging field of 'omics' research focusing on profiling and quantifying low-molecular weight components.
The POACH study is part of the Cardiosleep research program. It is a prospective, observational, multicentre study conducted in Singapore. The recruitment target is 1365 patients.
Eligible patients with AF and high cardiovascular risk will be recruited for a home-based sleep study using a FDA-approved portable device. The patients will be divided into 2 groups based on the presence or absence of OSA using apnoea-hypopnoea index ≥ 15 events/hour. The AF will be treated as per local standard practice. Follow-up will be conducted every 6 months until the median follow-up duration has reached 2 years. The primary endpoint is a four-component composite of all-cause mortality, myocardial infarction, stroke and heart failure hospitalisation. Antecubital venous blood samples will be taken from the patients in the morning after the sleep study for targeted mass spectrometry which will measure 83 circulating metabolites. Sparse Principal Component Analysis will be used for data reduction. Identification of distinct associations between metabolic perturbations and OSA will be performed.
Results of the POACH study will likely impact the care of patients with AF.
Interventions
- Diagnostic test Overnight sleep study
The patients will undergo an overnight sleep study using Watch-PAT sleep study device
Primary outcome measures
- Major adverse cardiovascular events [Time frame: 5 years]
Secondary outcome measures (8)
- All-cause mortality [Time frame: 5 years]
- All-cause mortality, myocardial infarction, or stroke [Time frame: 5 years]
- Cardiovascular death [Time frame: 5 years]
- Cardiovascular death, myocardial infarction, or stroke [Time frame: 5 years]
- Ischemic stroke [Time frame: 5 years]
- Heart failure hospitalisation [Time frame: 5 years]
- Recurrence of AF after attempts at rhythm control [Time frame: 5 years]
- AF Progression [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- Age 22 or above
- Known AF, including paroxysmal, persistent or permanent AF
- High cardiovascular risk, defined as one or more of the following:
- hypertension
- diabetes mellitus
- stroke
- significant coronary artery disease (at least one stenosis of >50% diameter in at least one major epicardial artery based on CT or conventional coronary angiography, positive stress test \[treadmill, myocardial perfusion scan, or stress echocardiography\], previous percutaneous coronary intervention, or previous coronary artery bypass surgery)
- chronic kidney disease (excluding polycystic kidney disease) with an estimated glomerular filtration rate of <60 ml/min/1.73m2,
- 10-year risk of cardiovascular disease of 15% or greater on the basis of the Framingham risk score, or
- age of 75 years or older
Exclusion criteria
- Known OSA on regular CPAP treatment
- Valvular AF (moderate/severe mitral stenosis or mechanical heart valve)
- Permanent pacemaker implantation
- Life expectancy less than 1 year based on concomitant medical conditions
- Unable to give research consent
- Pregnant or lactating women
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Singapore · 1 center
- Chi-Hang Lee — Singapore
Identifiers
NCT: NCT04005508 · POACH