Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: blood and urine samples.
- Who it may be relevant to
- Registry conditions: Organ Transplantation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Increased indications for transplantation continue to worsen the shortage of organs and need the extension of graft sampling criteria and the search for new potential sources of organs. Despite undeniable success in the short term, due to major advances in surgery, medicine and research, transplant recipients continue to face the risk of chronic rejection and long-term complications. The University Hospital Federation "FHU SUPORT" was created to optimize the chances of success of the organ transplant and improve the quality of life of the transplanted patient. FHU SUPORT 's ambition is based on a translational strategy that presents two priority areas: Axis 1: Optimization, evaluation, conditioning of the donor, graft, recipient Axis 2: Personalized follow-up of the transplanted patient in the short and long term Identifying factors for long-term graft and patient survival through translational research from a common cohort and biological collection will predict transplant rejection, prolong graft function, or improve the patient's care.
Interventions
- Other blood and urine samples
various blood and urine samples will be collected from the recipient at D0, D7, D14, M1, M3, M6 and M12 and intraoperative bile collection
Primary outcome measures
- Survival of the graft [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- Male or female over 18 (no age limit)
- affiliated to a social security organization
- Recipient (s) of a kidney, liver or heart transplant
- followed by at least one of the FHU SUPORT centers (Tours, Poitiers, Limoges, Rennes)
- having given informed consent to participate in the cohort.
Exclusion criteria
- Patient unable to understand the information given by the investigator
- People under the protection of justice
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 4 centers
- Limoges hospital — Limoges
- Poitiers Hospital — Poitiers
- Rennes Hospital — Rennes
- Tours hospital — Tours
Identifiers
NCT: NCT03997253 · 87RI18-0027