Clinical and Biological Database in Colon Cancer and Colic Tumors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Biological collection.
- Who it may be relevant to
- Registry conditions: Cancer Colon. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective, Multicenter, Clinical and Biological Database Set-up in Colon Cancer and Colic Tumors
Overview
Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.
Detailed description
As the second leading cause of cancer-related death in France, colorectal cancer is a major public health problem. Each year, 37 000 cases are newly diagnosed in France and 17 000 patients die of the disease.
Colorectal cancer is due to molecular and genetic damages involved in all tumorigenesis steps, transition from healthy tissue to adenoma and finally to invasive carcinoma stage. The investigators hope that a to better understand tumor invasion and metastatic scattering processes will allow therapeutic innovation and the emergence of new biomarkers.
However, the study of early tumorigenesis phases as well as advanced stages of the disease is currently limited due to a lack of tissue samples.
In this context, the Montpellier Cancer Institute (ICM) decided to initiate a biological collection dedicated to the tissular and blood samples of patients with colorectal cancer.
Interventions
- Other Biological collection
The biological collection will also include samples of blood samples collected before or after surgery but also samples frozen and/or paraffin-embedded tissue sections.
Primary outcome measures
- Number of clinical risk factors for colorectal cancer [Time frame: Until the study completion : 6 years]
- Number of biological risk factors for colorectal cancer [Time frame: Until the study completion : 6 years]
Eligibility criteria
Inclusion criteria
- Patient undergoing colon cancer surgery (stage I, II, III and IV)
- Patient operated for liver or lung or peritoneal carcinomatosis metastases originating from colon cancer
- Patient operated for pre-neoplastic lesion (adenomatous polyp /villous adenoma polyp),
- Patient with familial polyposis eligible for colectomy
- Age > 18 years
- Signed informed consent
Exclusion criteria
- Patient not affiliated to Social Protection system
- Patient unable to understand or comply with study instructions or requirements for psychological, family, social or geographical reasons
- Patient under guardianship
- Minor patient
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 2 centers
- CHRU de Montpellier — Montpellier
- Institut Régional du cancer de Montpellier — Montpellier
Identifiers
NCT: NCT03976960 · BCB2014/01