Smoking Cessation Behavioral Treatment Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT).
- Who it may be relevant to
- Registry conditions: Tobacco Use Disorder. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Neural Mechanisms Mediating Appetitive Regulation and Smoking in Nicotine Addiction
Overview
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
Interventions
- Behavioral Mindfulness-Oriented Recovery Enhancement (MORE)
MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. - Behavioral Cognitive Behavioral Therapy (CBT)
CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
Primary outcome measures
- Cigarette Smoking [Time frame: 7 weeks]
- Magnitude of change in fMRI brain response to images [Time frame: 7 weeks]
- Magnitude of change in fMRI brain connectivity [Time frame: 7 weeks]
Eligibility criteria
Inclusion criteria
- Age 18 and up
- English fluency as demonstrated in providing informed consent and the ability to independently follow directions in completing assigned assessments and tasks
- Functional vision (with corrective lenses as needed) to complete assigned assessments and tasks
- Current nicotine dependent smoker with a minimum smoking history of 2 years
- Interest in quitting smoking
Exclusion criteria
- Use of psychotropic (e.g. antiepileptic) medications in the past month
- Positive urine drug screen
- Presence of an untreated medical illness
- Current or past psychosis
- History of major neurological illness or head injury resulting in loss of consciousness
- And contraindication to MRI, including claustrophobia
- Among females, positive urine pregnancy test
- Inability or unwillingness of subject to give informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Basic science
Study locations
United States · 2 centers
- University of Missouri - Columbia — Columbia
- Medical University of South Carolina — Charleston
Identifiers
NCT: NCT03948893 · 2020602