Improving Glycemic Control With Electrical Stimulation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neuromuscular Electrical Stimulation (Sensory), Neuromuscular Electrical Stimulation, Resistance Training.
- Who it may be relevant to
- Registry conditions: Obesity, Overweight, Insulin Resistance. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Improving Glycemic Control With Electrical Stimulation in Mexican-Americans
Overview
Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55/15/30% CHO/PRO/FAT) prior to collection of pre-intervention data of insulin sensitivity. Individuals will then participate in an 8-week electrical stimulation intervention (30min/day, 3x/week) and randomized into placebo/control, NMES, resistance training combined with NMES (RT +NMES), or resistance training (RT) group (n=15 per group), followed by collection of post-intervention data. The control group will receive electrical stimulation up to sensory level, the NMES group will receive stimulation up to tolerable intensity to induce visible muscle contraction, the RT+ NMES will receive stimulation up to tolerable intensity during resistance training, and the RT group will only receive exercise training. Pre-and post-intervention data includes measurements for body composition, resting metabolic rate, VO2max, insulin sensitivity, and comprehensive blood work.
Interventions
- Device Neuromuscular Electrical Stimulation (Sensory)
Group will receive Electrical Stimulation up to sensory level - Device Neuromuscular Electrical Stimulation
Group will receive Electrical Stimulation up to maximum tolerable level - Other Resistance Training
Group will receive exercise training.
Primary outcome measures
- Glycemic Control [Time frame: 8 weeks]
Secondary outcome measures (2)
- Respiratory Exchange Ratio [Time frame: 8 Weeks]
- Amount of lean mass [Time frame: 8 Weeks]
Eligibility criteria
Inclusion criteria
- Overweight/Obese (BMI ≥25)
- Sedentary Lifestyle: Physical Activity Level<1.4
- Less than 150min/week of structured Exercise
Exclusion criteria
- Use of anti-hypertensive, lipid-lowering or insulin sensitizing medications
- Excessive alcohol, drug abuse, smoking
- Pregnant Women
- Unwilling to adhere to the study Intervention
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- University of Texas at El Paso — El Paso
Publications
- Apaflo JN, Narvaez G, Tomy IJ, Mossayebi A, Fatahimeiabadi Z, McAinch AJ, Thyfault JP, Min K, Jung H, Wagler AE, Bajpeyi S. Neuromuscular electrical stimulation enhances glycemic control and carbohydrate utilization in sedentary, predominantly Hispanic overweight or obese individuals with hyperglycemia. Eur J Appl Physiol. 2026 Jan;126(1):469-477. doi: 10.1007/s00421-025-05907-x. Epub 2025 Jul 28. PMID 40721518
Identifiers
NCT: NCT03947697 · 1233722