Gene Expression Changes In Young and Geriatric Skin
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Insulin-Like Growth Factor 1, No Insulin-Lie Growth Factor 1.
- Who it may be relevant to
- Registry conditions: UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging. Basic parameters: from 21 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Gene Expression Changes in Young and Geriatric Skin
Overview
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Interventions
- Drug Insulin-Like Growth Factor 1
Growth factor protein - Other No Insulin-Lie Growth Factor 1
No Insulin-Like Growth Factor 1 will be given.
Primary outcome measures
- Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline [Time frame: 2 Days]
Eligibility criteria
Inclusion criteria
- Male/Female
- White skin (Fitzpatrick types I and II)
- Age 21-30 or 65 and older
- Able to comprehend procedures/risks
Exclusion criteria
- Known photosensitivity
- Currently on photosensitizing medications
- Diabetes Mellitus
- History of abnormal scarring
- History of skin infections
- Known allergy to lidocaine local anesthetic
- Pregnancy or nursing
- Other serious health issues
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Wright State Physicians — Fairborn
Identifiers
NCT: NCT03932162 · 06694