Transcriptome Profiling and Endometrial Receptivity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: endometrial biopsy and blood sampling.
- Who it may be relevant to
- Registry conditions: Pregnancy Related. Basic parameters: 20 years — 40 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Hong Kong
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Transcriptome Profiling and Immune/ Biochemical Markers of Peripheral Blood to Predict Endometrial Receptivity and Successful Implantation
Overview
The aim of this study is to correlate and identify the biochemical markers which may reflect WOI. Blood samples will be collected and endometrial biopsy will be performed at particular time points.
Detailed description
Endometrial receptivity in the midluteal phase of the menstrual cycle, known as the window of implantation (WOI), occurs only for a very short period of time. However, so far, there is no reliable clinical and biochemical indicators of WOI. Therefore, this study is to correlate and identify the biochemical markers which may reflect WOI.
participants will be asked to be:
1. performed endometrial biopsy 2. taken blood for a few time points (e.g. pre-conception and being pregnant) and to compare different kinds of biochemical markers.
Interventions
- Procedure endometrial biopsy and blood sampling
patient will be performed endometrial biopsy and collected blood samples at particular time points
Primary outcome measures
- The change of the transcriptome profiling in the peripheral blood [Time frame: From the day of endometrial biopsy through study completion, an average of 2 months]
- The change of the immune markers in the peripheral blood [Time frame: From the day of endometrial biopsy through study completion, an average of 2 months]
Eligibility criteria
Inclusion criteria
Age 20-40 years.
Exclusion criteria
- Uncorrected uterine anomalies, such as septate or bicornuate uterus, fibroids (submucous/intramural).
- Intrauterine adhesions.
- Adenomyosis.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Other
Study locations
Hong Kong · 1 center
- Chinese University of Hong Kong — Hong Kong
Identifiers
NCT: NCT03925311 · 2014.637