Efficacy of Nitrous Oxide in OCD: Pilot Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Nitrous Oxide, Nitrogen.
- Who it may be relevant to
- Registry conditions: Obsessive-Compulsive Disorder. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.
Detailed description
Obsessive-compulsive disorder (OCD) is a chronic and disabling disorder characterized by recurrent intrusive thoughts and associated compulsive behaviors that is estimated to affect more than 3 million individuals in the US each year.
This study seeks to explore whether a single inhalation of nitrous oxide gas may bring about rapid symptom relief in OCD.
Interventions
- Drug Nitrous Oxide
OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes. - Drug Nitrogen
OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes.
Primary outcome measures
- Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS) [Time frame: 1 week]
Eligibility criteria
Inclusion criteria
- Age 18-65
- Primary diagnosis of OCD
- Sufficient severity of OCD symptoms
- Ability to tolerate a treatment-free period
- Capacity to provide informed consent
Exclusion criteria
- Psychiatric or medical conditions that make participation unsafe
- Pregnant or nursing females
- Concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Stanford University — Stanford
Identifiers
NCT: NCT03826693 · 48077