Blood Sampling of Healthy Volunteers for Immunological Research
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood sample.
- Who it may be relevant to
- Registry conditions: Healthy Volunteers. Basic parameters: from 36 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Netherlands
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This protocol will be used to collect crucial components of the immune system from healthy volunteers for the characterization of immune cells in fresh blood. A pipeline has been set up for comprehensive immune phenotyping of both lymphoid and myeloid cells within 24 hours after blood withdrawal.
Detailed description
In order to properly compare the immunobiology of healthy volunteers to (advanced) cancer patients, the investigators use age-matched controls with no history of cancer and no potentially interfering medication.
Healthy volunteers will be asked to donate 5 tubes of blood
Interventions
- Other Blood sample
Blood sample
Primary outcome measures
- The number of immune cells, both lymphoid and myeloid, present in the blood of healthy individuals, assessed by flow cytometry, as well as cytokine expression and transcriptome profiles of these cells [Time frame: assessed up to 12 months]
Secondary outcome measures (1)
- Immunophenotyping of both myeloid and lymphoid cells in healthy individuals [Time frame: assessed up to 12 months]
Eligibility criteria
Inclusion criteria
- Age above 35 years
- Written informed consent
- No history of cancer
- No use of systemic immunosuppressive medication (eg. corticosteroids). Local use of corticosteroids (eg. topical or inhalation) is allowed.
Exclusion criteria
- Fever 14 days before blood withdrawal
- Donated blood for the same program within the last 2 years
- Pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Netherlands · 1 center
- NKI-AVL — Amsterdam
Identifiers
NCT: NCT03819829 · B18HIR