Enhancing Renal Graft Function During Donor Anesthesia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Mannitol infusion, Dopamine infusion, Adequate hydration.
- Who it may be relevant to
- Registry conditions: Renal Failure Chronic, Transplant;Failure,Kidney, Anesthesia. Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities
Overview
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess \& compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.
Interventions
- Procedure Mannitol infusion
Infusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes. - Procedure Dopamine infusion
Infusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery. - Procedure Adequate hydration
Infusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.
Primary outcome measures
- Post-operative creatinine clearance [Time frame: 7 days]
Eligibility criteria
Inclusion criteria
- end-stage renal disease, for living-donor kidney transplantation
Exclusion criteria
- severe cardiac or hepatic dysfunction
- coagulopathy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Supportive care
Study locations
Egypt · 1 center
- Kasr Al-Ainy Hospital, Cairo University — Cairo
Identifiers
NCT: NCT03778944 · RGFEDDA