Inflammatory Mediators of Acute Kidney Injury in Intensive Care
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Sepsis, Surgery, Acute Kidney Injury. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury
Overview
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.
Primary outcome measures
- Histones [Time frame: Within 1 month]
Secondary outcome measures (1)
- Other inflammtory mediators [Time frame: Within 1 month]
Eligibility criteria
Inclusion criteria
Patients admitted to the intensive/post operative care unit
- with septic shock or
- post major surgery or
- after intoxication with a chemical compund
Exclusion criteria
- Pregnancy or
- Breast feeding or
- Chronic kidney disease or
- intoxication with nephrotoxic compund or
- lack of informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Sweden · 1 center
- Akademiska sjukhuset, Centraloperation — Uppsala
Publications
- Karlsson PA, Bolin C, Spang L, Frithiof R, Hultstrom M, Lipcsey M, Wang H, Jarhult JD. Bacteriuria and antibiotic use during the third wave of COVID-19 intensive care in Sweden. Infect Dis (Lond). 2025 Mar;57(3):284-293. doi: 10.1080/23744235.2024.2423884. Epub 2024 Nov 7. PMID 39509144
Identifiers
NCT: NCT03720860 · 2017-043PronMed