Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MRI acquisitions.
- Who it may be relevant to
- Registry conditions: Magnetic Resonance Imaging Sequences. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. These new sequences will allow better spatial resolution and specificity while reducing acquisition time.
Detailed description
The purpose of the present study is to test and optimize, on healthy subjects, specific MRI acquisition sequences firstly developed in a preclinical phase on phantoms (inert objects containing solutions or gels) and animal (Pig, sheep). This study will allow the investigators to define practical acquisition parameters that will allow reproducible results and precise definition of clinically relevant examination protocols for each new developed sequence.
Interventions
- Device MRI acquisitions
Procedure of the study is an MRI exam without any injection or invasive procedure, that will be performed on the Siemens Magnetom Aera imager of Liryc institute (L'Institut de RYthmologie et modélisation Cardiaque) (Xavier Arnozan site - Bordeaux)
Primary outcome measures
- Image quality [Time frame: Day 0]
- Signal to noise ratio [Time frame: Day 0]
- Contrasts between structurally different regions [Time frame: Day 0]
- Total acquisition time [Time frame: Day 0]
- Qualitative interpretation of image quality to respiratory and cardiac motions [Time frame: Day 0]
- Quantitative interpretation of image quality to respiratory and cardiac motions [Time frame: Day 0]
Eligibility criteria
Inclusion criteria
- Healthy volunteers (over 18 yo),
- Male or female,
- Affiliated to social security,
- Without any contraindication to MRI exam and who will have signed a written inform consent.
Exclusion criteria
- Individuals deprived of liberty,
- Under guardianship or curatorship,
- Persons with known disease which could disturb MRI acquisition or with absolute or relative contraindication to an MRI examination
- Pregnant women,
- Breastfeeding women,
- Women without effective contraception,
- Participants who refused to be informed of the possible discovery of a significant anomaly,
- Persons involved in an interventional study with a drug or an implantable device.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 1 center
- CHU de Bordeaux — Pessac
Identifiers
NCT: NCT03674645 · CHUBX 2017/21