Maternal Grandmothers in the Born in Guangzhou Cohort Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Hereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome. Basic parameters: 36 years — 100 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
Detailed description
It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.
Interventions
- Other
Primary outcome measures
- Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring [Time frame: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth]
Secondary outcome measures (7)
- Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life [Time frame: At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren]
- The prevalence of eczema of grandchildren [Time frame: At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
- The incidence of asthma of grandchildren [Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
- The prevalence of Allergic rhinitis of grandchildren [Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
- The prevalence of Food allergy of children and grandchildren [Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
- Changes of body composition of grandchildren [Time frame: At age of 3 years,6 years, 12years and 18years]
- Changes of bone density of grandchildren [Time frame: At age of 3 years,6 years, 12years and 18years]
Eligibility criteria
Inclusion criteria
- Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
- Baseline information of maternal grandmother's daughter during pregnancy available
Exclusion criteria
- Significant cardiovascular abnormalities
- Intelligent obstacle, intellectual disabilities or gawkish condition
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Guangzhou Women and Children's Medical Center — Guangzhou
Publications
- Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. PMID 28321694
- Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23. PMID 26213383
Identifiers
NCT: NCT03633162 · 2018041801 · 81673181 · 201508030037