Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Lower body negative pressure.
- Who it may be relevant to
- Registry conditions: Hypovolemia, Hemodynamic Instability. Basic parameters: 20 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.
Detailed description
The primary aim of this research is to identify the most robust site for monitoring hypovolemia as well as assess changes in peripheral waveforms monitored by the pulse oximeter collected from different sites (finger, ear, forehead, and nose), blood pressure, cerebral oximetry and peripheral venous pressure during gradual hypovolemia induced by lower body negative pressure (LBNP) in healthy volunteers.
Interventions
- Diagnostic test Lower body negative pressure
We will be monitoring the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.
Primary outcome measures
- Identify the most robust site for monitoring hypovolemia utilizing pulse oximeter waveforms. [Time frame: 2 years]
Secondary outcome measures (1)
- Examine the relationship between central hemodynamic changes (cardiac output) with changes in respiratory variability of PPG waveforms collected from different sites during hypovolemia and fluid resuscitation [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
\* Healthy volunteers aged 20-45 with
Exclusion criteria
- Pregnant women
- Under 20 years of age
- Subjects with coronary artery disease, diabetes, epilepsy and hypertension
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-only
Study locations
United States · 1 center
- John B. Pierce Laboratory — New Haven
Identifiers
NCT: NCT03592290 · 2000020057 · 000