Genetic Variants and Postoperative Pain
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Postoperative Pain, Analgesia, Surgical Procedure, Operative. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Prospective observational study to analyse patients' pain related outcome after surgery and ist association to genetic variants and non-genetic variables.
Detailed description
Background
Severe acute pain as well as long-lasting pain after surgery and pain-related interference of daily activities are frequent. Some risk factors for severe pain after surgery in adults have been described, e.g. younger age and pre-existing chronic pain. The question arises whether a specific genetic background is related to an unfavorable pain outcome.
Objective
The aim of this study is to investigate clinical and genetic variables and their possible association to severe acute postoperative pain, higher analgesic consumption and the development of chronic postsurgical pain.
Methods
Prospective observational study investigating clinical, patient related, surgery related and anesthesia related variables as well as genetic variants and their possible association to patients' pain related outcome after surgery.
Primary outcome measures
- Pain related impairment after surgery and its association to genetic and non-genetic variables [Time frame: day of surgery up to 1 year after surgery]
Secondary outcome measures (3)
- Association of genetic and non-genetic variables with analgesic consumption [Time frame: day of surgery up to one year after surgery]
- Association of genetic and non-genetic variables with pain related outcome of patients 1 year after surgery [Time frame: Up to one year after surgery]
- Association of genetic and non-genetic variables with chronic neuropathic postsurgical pain [Time frame: up to one year after surgery]
Eligibility criteria
Inclusion criteria
- 18 years and older
- Written informed consent
- Elective surgery
- Patients' ability to understand the purpose of the study
Exclusion criteria
- No informed consent
- Cognitive impairment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Switzerland · 1 center
- Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern — Bern
Identifiers
NCT: NCT03489499 · 041/09c Schmerz