New MRI Biomarkers in Head and Neck Cancers
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MRI examinations, MRI examinations.
- Who it may be relevant to
- Registry conditions: Head and Neck Cancer, Thyroid Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Quantitative Imaging Tools to Derive DW-MRI Oncological Biomarkers
Overview
Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt. This makes specific organs, blood vessels, or tumors easier to see. Diffusion MRI lets us measure the motion of water in the tumor. The purpose of this study is to see if new MRI methods can give us more information about the tumor.
Interventions
- Other MRI examinations
Patients will be imaged on a 1.5 T or 3 T MR scanner either from GE or Philips. Patients will receive a test-retest scan in on session prior to start of treatment. Patients who will be receiving radiation therapy treatment at main campus, will also be imaged weekly during their course of treatment. - Other MRI examinations
Patients will be imaged on a 1.5 T or 3T MR scanner within one week prior to treatment initiation and at two months and four months after treatment completion (+/- 1 week).
Primary outcome measures
- For group 1: number of patients that have biomarkers that maybe early response to therapy indicators [Time frame: 1 year]
- For group 2: number of patients response to treatment [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years
- Group 1 patients: Presence of a suspicious metastatic lesion or suspicious for recurrent disease in the head and neck region.
- Group 2 patients:
- Biopsy proven recurrent or metastatic or definitive head and neck cancer or (differentiated and undifferentiated) thyroid cancers in the head and neck region only.
- Patients planning to undergo reatment at MSK
Exclusion criteria
- Patient would require anesthesia for the study
- Patients who are claustrophobic
- Patients selecting treatment outside of MSK
- Known reaction to Gd based contrast agent
- Patients who have presence of a known contradiction to MRI
- Pacemaker
- Aneurysm clips
- Patients with implants that are contradicted for MR imaging will be excluded
- Pregnant
- Age and mental status wherein he /she is unable to cooperate for MRI study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Memorial Sloan Kettering Cancer Center — New York
Identifiers
NCT: NCT03483337 · 18-063