A Prospective Cohort Study for Patients With Adrenal Diseases
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hormone study and Imaging study.
- Who it may be relevant to
- Registry conditions: Adrenal Adenoma, Cushing Syndrome, Pheochromocytoma, Adrenal Incidentaloma. Basic parameters: from 19 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.
Detailed description
The investigators will recruit 150 patients annually for 10 years (adrenal incidentaloma 100 patients, pheochromocytoma 15 patients, primary aldosteronism 25 patients, adrenal cushing syndrome 10 patients, adrenocortical carcinoma 2 patients) and perform hormonal, biochemical, imaging exam according to each disease's clinical guidelines. Based on this, the investigators will identify pathologic features, complications, and prognostic factors of each disease.
Interventions
- Other Hormone study and Imaging study
1. Blood (basal hormone and follow up hormone study) 2. Imaging examination including computed tomography scan or magnetic resonance imaging
Primary outcome measures
- Number of participants in remission [Time frame: Up to 10 years]
Secondary outcome measures (1)
- Complication of adrenal disease [Time frame: Up to 10 years]
Eligibility criteria
Inclusion criteria
- Adults, male or female aged 19 years or older
- newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma, primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma
Exclusion criteria
- previous or current history of adrenal diseases
- using oral or intravenous steroids
- history of major depressive disorder
- history of chronic alcoholics
- history of any cancer with suspicious adrenal metastasis
- those with acute illness (ex- patients with acute coronary syndrome within 4 weeks, acute febrile disease)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
South Korea · 1 center
- Seoul National University Hospital — Seoul
Identifiers
NCT: NCT03474237 · 1801-010-911