Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No intervention.
- Who it may be relevant to
- Registry conditions: Posterior Reversible Encephalopathy Syndrome. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Posterior Reversible Encephalopathy Syndrome prospective (PRES) registry. Data collection using a standardized form : demographic data and data related to the PRES, including circumstances of onset, dates and times of onset and of symptoms control, on-scene clinical findings, clinical and radiological features of PRES, pre-hospital and hospital care providers, timing of antiepileptic, antihypertensive drugs and supportive treatments, results of etiological investigations, cause of PRES, type and dosage of antiepileptic and antihypertensive drugs. Dates and times of EEG monitoring, EEG results, radiological and biological investigations. Outcomes including vital status and Glasgow Outcome Scale score at ICU and hospital discharge, day-90 and 1-year after SE and determined based on data in the ICU and/or neurologist charts and/or patients phone interview
Interventions
- Other No intervention
No intervention planed
Primary outcome measures
- Favorable outcome [Time frame: 1 year]
Secondary outcome measures (5)
- Favorable outcome [Time frame: 3-months and 5-years, 10-years]
- Functional impairment [Time frame: 3-months and 1-year, 5-years, 10-years]
- Low or moderate disability [Time frame: 3-months and 1-year, 5-years, 10-years]
- Recurrent PRES [Time frame: 3-months and 1-year, 5-years, 10-years]
- Mortality rate [Time frame: ICU, hospital discharge, 3-months and 1-year, 5-years, 10-years]
Eligibility criteria
Inclusion criteria
- age >= 18 years
- Posterior Reversible Encephalopathy Syndrome defined as:
- combination of consciousness impairment, seizure activity, headaches, visual abnormalities, nausea/vomiting, and focal neurological signs AND
- cerebral imaging abnormalities involving the white matter (brain CT scan hypodensities AND/OR Brain MRI hypoT1, hyper T2 FLAIR)
- intensive care unit admission
Exclusion criteria
- normal cerebral imaging
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Intensive Care Unit - Versailles Hospital — Le Chesnay
Identifiers
NCT: NCT03470467 · ICTAL PRES REGISTRY