Bariatric Surgery and Pharmacokinetics of Escitalopram
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Escitalopram.
- Who it may be relevant to
- Registry conditions: Obesity, Morbid. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Norway
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Bariatric Surgery and Pharmacokinetics Escitalopram: BAR-MEDS Escitalopram
Overview
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on escitalopram are investigated.
Interventions
- Drug Escitalopram
Patients are tested for their normal prescription escitalopram medication
Primary outcome measures
- Escitalopram concentration in blood serum (area under curve (AUC)) [Time frame: From baseline to 1 year postoperatively]
Eligibility criteria
Inclusion criteria
- Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- Being a Norwegian citizen
Exclusion criteria
- Having previously undergone resections in the GI-tract
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
Norway · 1 center
- St. Olavs University Hospital — Trondheim
Publications
- Schoretsanitis G, Strommen M, Krabseth HM, Helland A, Spigset O. Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Escitalopram Pharmacokinetics: A Cohort Study. Ther Drug Monit. 2023 Dec 1;45(6):805-812. doi: 10.1097/FTD.0000000000001114. Epub 2023 Jun 15. PMID 37363832
Identifiers
NCT: NCT03460379 · 2016/1145k