Status Epilepticus in the Critically Ill Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Status Epilepticus. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset, dates and times of onset and of seizure control, on-scene clinical findings, clinical features of the seizures, pre-hospital and hospital care providers, timing of antiepileptic and supportive treatments, results of etiological investigations, cause of SE, type and dosage of antiepileptic drugs. Dates and times of EEG monitoring, EEG results. Outcomes including vital status and Glasgow Outcome Scale score at ICU and hospital discharge, day-90 and 1-year after SE and determined based on data in the ICU and/or neurologist charts and/or patients phone interview.
Primary outcome measures
- Favorable outcome [Time frame: 1 year]
Secondary outcome measures (8)
- Favorable outcome [Time frame: 3 months, 5-years and 10 years]
- Functional impairment [Time frame: 3 months, and 1-year, 5-years and 10-years]
- total seizure duration [Time frame: 72 hours]
- percentages of the patients that experience recurrent convulsive and/or non-convulsive seizures within 12 hours after ICU admission [Time frame: 12 hours]
- refractory status epilepticus [Time frame: 24 hours]
- super refractory status epilepticus [Time frame: 72 hours]
- total ICU and in-hospital length of stay [Time frame: 90 days]
- mortality rate [Time frame: ICU and hospital discharge, 3-months, and 1-year, 5 years and 10 years]
Eligibility criteria
Inclusion criteria
- SE defined as 5 min or more of (i) continuous clinical and/or electrographic seizure activity or (ii) recurrent seizure activity without recovery (returning to baseline) between seizures.
- age >= 18 years
Exclusion criteria
- age < 18 years
- postanoxic status epilepticus
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
France · 20 centers
- CH Angouleme - Service de réanimation polyvalente — Angoulême
- CH de Beauvais - Service de réanimation polyvalente — Beauvais
- CH de Bethune - Service de Réanimation et Surveillance continue — Beuvry
- Centre Hospitalier Universitaire Régional — Brest
- CH Brive La Gaillarde - Service de réanimation - USC — Brive-la-Gaillarde
- CH de Cannes — Cannes
- CH Public du Cotentin - Service de Réanimation - Médecin intensive — Cherbourg
- CHU Beaujon — Clichy
- … and 12 more centers
Publications
- Bouquot M, Chelly J, Quenot JP, Lascarrou JB, Bernard C, Monchi M, Beuret P, Sigaud F, Sboui G, Bailly P, Chambon R, Fontaine C, Mongardon N, Cerf C, Bruel C, Pichon N, Argaud L, Kinane M, Desmeulles I, Kifouche F, Hassani ML, Boubekri A, Vieille T, Marzouk M, Ravaux H, Schnell D, Sedillot N, Brunel M, Jacq G, Lesieur O, Legriel S. Potentially Surgical Digestive Complications in Patients With Stat PMID 42206939
- Vieille T, Jacq G, Merceron S, Huriaux L, Chelly J, Quenot JP, Legriel S. Management and outcomes of critically ill adult patients with convulsive status epilepticus and preadmission functional impairments. Epilepsy Behav. 2023 Apr;141:109083. doi: 10.1016/j.yebeh.2023.109083. Epub 2023 Feb 18. PMID 36803873
- Chinardet P, Gilles F, Cochet H, Chelly J, Quenot JP, Jacq G, Soulier P, Lesieur O, Beuret P, Holleville M, Bruel C, Bailly P, Sauneuf B, Sejourne C, Galbois A, Fontaine C, Perier F, Pichon N, Arrayago M, Mongardon N, Schnell D, Lascarrou JB, Convers R, Legriel S. Electrocardiographic Changes at the Early Stage of Status Epilepticus: First Insights From the ICTAL Registry. Crit Care Med. 2023 Mar PMID 36533915
- Jacq G, Chelly J, Quenot JP, Soulier P, Lesieur O, Beuret P, Holleville M, Bruel C, Bailly P, Sauneuf B, Sejourne C, Rigaud JP, Galbois A, Arrayago M, Plantefeve G, Stoclin A, Schnell D, Fontaine C, Perier F, Bougouin W, Pichon N, Mongardon N, Ledoux D, Lascarrou JB, Legriel S. Multicentre observational status-epilepticus registry: protocol for ICTAL. BMJ Open. 2022 Feb 15;12(2):e059675. doi: 10.1 PMID 35168989
Identifiers
NCT: NCT03457831 · ICTAL SE REGISTRY