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Recruiting NCT03346772

Study of Immune Responses to Influenza Vaccination

Phase IV Interventional Influenza Vaccination

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Influenza vaccination.
Who it may be relevant to
Registry conditions: Influenza Vaccination. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

Interventions

  • Biological Influenza vaccination
    Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Primary outcome measures

  • Influenza neutralizing antibody titers [Time frame: 21-42 days]

Eligibility criteria

Inclusion criteria

  • Community-dwelling adults able to provide consent who need influenza vaccination for standard of care

Exclusion criteria

  • febrile illness at time of vaccination
  • active malignancy
  • use of immunosuppressing medications
  • blood donation in the past 60 days
  • influenza vaccinated during the preceding 6 months
  • allergic reactions to influenza vaccination

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Basic science

Study locations

United States · 1 center
  • University of Pennsylvania — Philadelphia

Identifiers

NCT: NCT03346772 · 820590

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗