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Recruiting NCT03335644

The NutriNet-Santé Study

— Observational Diet, Food, and Nutrition Exercise Diseases Category Cohort Studies

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Diet, Food, and Nutrition, Exercise, Diseases Category, Cohort Studies. Basic parameters: from 15 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors

Overview

The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior. https://etude-nutrinet-sante.fr/ https://info.etude-nutrinet-sante.fr/en

Detailed description

NutriNet-Santé is a large-scale (n=171,000) web-based cohort coordinated by EREN, launched in France in 2009 to investigate nutrition and health relationships. All required ethics authorisations have been obtained (listed here). NutriNet-Santé participants regularly fill questionnaires through a dedicated and secure website, providing extensive, high-quality nutritional and non-nutritional data, including repeated data on socio-demographics and lifestyle (yearly), anthropometrics (every 6 months), dietary intake (every 6 months), physical activity (IPAQ questionnaire, yearly)5 and health status (every 6 months). NutriNet-Santé is characterised by a very detailed and up-to-date assessment of nutritional exposure and dietary behaviours. Usual dietary intakes are assessed at baseline and every 6 months thereafter through a series of 3 non-consecutive randomly assigned 24h dietary records. Daily energy, alcohol, micro- and macronutrient intakes are calculated using the published NutriNet-Santé food composition database (\>3,500 generic items). All major health events (e.g., cancers, cardio- and cerebrovascular diseases) are reported by the participants and validated by an expert committee of physicians based on medical records, and/or retrieved from the French National Health Insurance medico-administrative databases to limit potential reporting bias. In turn, mortality data are obtained from the exhaustive French National Mortality Registry (CépiDC). The number of incident events already registered is as follows: 4,200 cancers and 1,240 deaths. A sub-sample of the cohort (n=20,000) provided blood and urine samples, currently stored at -80°C in EREN's biobank.

Primary outcome measures

  • cancers using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • CVD using health questionnaire and/or the dedicated website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • type 2 diabetes using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • hypertension using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • metabolic syndrome using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • depression using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • migraine using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • rheumatoid arthritis using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • cognitive decline using health questionnaire and/or the website for declaration of major health events [Time frame: every 6 months after registration, up to 10 years of follow-up]
  • quality of life using the SF-36 questionnaire [Time frame: every 6 months after registration, up to 10 years of follow-up]

Eligibility criteria

Inclusion criteria

  • aged over 15 years
  • access to internet

Exclusion criteria

  • aged under 15 years

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

France · 1 center
  • EREN — Bobigny

Publications

  • Hercberg S, Castetbon K, Czernichow S, Malon A, Mejean C, Kesse E, Touvier M, Galan P. The Nutrinet-Sante Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status. BMC Public Health. 2010 May 11;10:242. doi: 10.1186/1471-2458-10-242. PMID 20459807
  • Hasenbohler A, Javaux G, Payen de la Garanderie M, Szabo de Edelenyi F, Yvroud-Hoyos P, Agaesse C, De Sa A, Huybrechts I, Pierre F, Coumoul X, Fezeu LK, Galan P, Blacher J, Julia C, Alles B, Hercberg S, Chassaing B, Deschasaux-Tanguy M, Srour B, Touvier M. Preservative food additives, hypertension, and cardiovascular diseases: the NutriNet-Sante study. Eur Heart J. 2026 May 20:ehag308. doi: 10.109 PMID 42161430
  • Larnder AH, Murphy RA, Srour B, Dechamp N, Galan P, Hercberg S, Bourhis L, Diaz C, Genilloud O, Touvier M, Deschasaux-Tanguy M. Plasma metabolites, dietary intakes, and breast cancer incidence: a prospective case-cohort study in NutriNet-Sante. Am J Clin Nutr. 2026 Jul;124(1):101342. doi: 10.1016/j.ajcnut.2026.101342. Epub 2026 May 23. PMID 42114757
  • Berlivet J, Meyer E, Alles B, Lairon D, Hercberg S, Touvier M, Srour B, Baudry J, Kesse-Guyot E. Consumption of organic compared with conventional fruits and vegetables in relation to cancer risk: findings from the NutriNet-Sante cohort study. Am J Clin Nutr. 2026 May;123(5):101284. doi: 10.1016/j.ajcnut.2026.101284. Epub 2026 Mar 19. PMID 41862000
  • Hasenbohler A, Javaux G, Payen de la Garanderie M, Szabo de Edelenyi F, Bourhis L, Agaesse C, De Sa A, Huybrechts I, Pierre F, Coumoul X, Julia C, Kesse-Guyot E, Alles B, Fezeu LK, Hercberg S, Deschasaux-Tanguy M, Cosson E, Tatulashvili S, Chassaing B, Srour B, Touvier M. Associations between preservative food additives and type 2 diabetes incidence in the NutriNet-Sante prospective cohort. Nat Co PMID 41501013
  • Hasenbohler A, Javaux G, Payen de la Garanderie M, de Edelenyi FS, Yvroud-Hoyos P, Agaesse C, De Sa A, Huybrechts I, Pierre F, Audebert M, Coumoul X, Julia C, Kesse-Guyot E, Alles B, Deschamps V, Hercberg S, Chassaing B, Srour B, Deschasaux-Tanguy M, Touvier M. Intake of food additive preservatives and incidence of cancer: results from the NutriNet-Sante prospective cohort. BMJ. 2026 Jan 7;392:e08 PMID 41500678
  • Cote M, Hutchinson JM, Touvier M, Srour B, Bourhis L, Lamarche B, Fezeu LK. Associations between Dietary Pattern Networks Derived from Machine Learning Algorithms and Cardiovascular Disease Risk in the NutriNet-Sante Cohort. J Nutr. 2025 Nov;155(11):4033-4042. doi: 10.1016/j.tjnut.2025.09.014. Epub 2025 Sep 22. PMID 40992665
  • Paz-Graniel I, Kose J, Duquenne P, Babio N, Salas-Salvado J, Hercberg S, Galan P, Touvier M, Fezeu LK, Andreeva VA. Alcohol, Smoking, and Their Synergy as Risk Factors for Incident Type 2 Diabetes. Am J Prev Med. 2025 Nov;69(5):108011. doi: 10.1016/j.amepre.2025.108011. Epub 2025 Jul 31. PMID 40752888

Identifiers

NCT: NCT03335644 · NutriNet-Santé

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗