Sensori-motor and Perceptual Functions of the PPC.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: point targets, tactile stimulation, visual images.
- Who it may be relevant to
- Registry conditions: Healthy Volunteers, Optic Ataxia. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.
Overview
To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles. The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning. In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests. Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.
Interventions
- Behavioral point targets
In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark. - Behavioral tactile stimulation
In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation. - Behavioral visual images
Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.
Primary outcome measures
- response error - number of pointing error [Time frame: Day 0 after each stimulation]
- response error -measure of reaction times [Time frame: Day 0 after each stimulation]
- response error - percentage of right responses [Time frame: Day 0 after each stimulation]
Eligibility criteria
Inclusion criteria
All patients and healthy subjects:
- male and female, age from 18 to 75 years included
- normal vision or corrected vision
- covered by social security
- signed written informed consent
Patients:
- neurological injury in posterior parietal cortex supported by a cerebral MRI
- present optic ataxia symptoms Healthy subjects
- no known neurological injury
Exclusion criteria
\- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
France · 1 center
- U1028 INSERM - CNRS UMR 5292 Equipe ImpAct — Bron
Identifiers
NCT: NCT03286686 · 69HCL17_0341 · 2017-A02562-51