Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neurophysiological assessment, Neuropsychological assessment.
- Who it may be relevant to
- Registry conditions: Healthy Volunteer. Basic parameters: 1 year — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
It is now widely accepted that autism is linked to a developmental disorder and cerebral function. Our research team (UMR U930 INSERM, François-Rabelais University of Tours, whom Pr F Bonnet-Brilhault is responsible for team "Autism") hypothesizes that atypical sensory information processing, especially auditory and / or visual information, could underly the symptoms observed in autism. A better knowledge of the typical development of the sensory and cognitive processes must therefore make it possible in the long term to identify the abnormalities linked to the autism spectrum disorders (ASD). Studies in healthy subjects are therefore necessary in order to identify neurophysiological indices of cerebral functioning and to study their evolution during normal development, making it possible in the future to compare with populations of subjects with ASD. The investigators intend to study the development of all the cognitive processes involved in the processing of sensory and, in particular, auditory and visual information in humans: from low-level perception processes to higher-level cognitive processes (attention, emotion, language, prediction, ...). For this the investigators will use non-invasive neurophysiological explorations (EEG, eye tracking) as well as neuropsychological explorations (Questionnaires or spontaneous language recording). A better understanding of the pathophysiological mechanisms underlying the symptoms observed in autism could ultimately lead to the development of new specific therapeutic strategies, particularly in the field of exchange and development therapy or cognitive remediation .
Interventions
- Behavioral Neurophysiological assessment
Assessment of cerebral electrical activity Assessment of ocular exploration Neurovegetative assessments - Behavioral Neuropsychological assessment
sub-tests, scales, surveys, reaction time measurement
Primary outcome measures
- ERP amplitude (µV) [Time frame: 1 hour]
Secondary outcome measures (2)
- Reaction times (ms) [Time frame: 1 hour]
- pupil size (mm) [Time frame: 1 hour]
Eligibility criteria
Inclusion criteria
- Between 1 and 60 years-old
- Able to understand and apply instructions for a task
- Information of subject or legal representant
- Informed written consent of subject or legal representant
- Affiliation to the social security system
Exclusion criteria
- Abnormal corrected vision
- Abnormal audition
- Known personal neurological pathology
- Known personal psychiatric problems
- Identified difficulties for walking, language, or learning
- Exclusion period because of participation to another experimental protocol
- Adult with legal protection
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
France · 1 center
- Chru Tours — Tours
Identifiers
NCT: NCT03182400 · PHAO17-FBB/PROSCEA