An Observational Study on Epithelioid Sarcoma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Treatment for Epitheloid Sarcoma.
- Who it may be relevant to
- Registry conditions: Epithelioid Sarcoma. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Epithelioid Sarcoma. An Observational Study
Overview
Prospective Italian study aimed to provide a description of the population affected by Epithelioid Sarcoma (ES)
Detailed description
The present prospective national study aims to provide a description of the population affected by ES, an insight into the natural history of the disease and an answer some on the outstanding questions on its management. Also, it will focus on enhancing any differences between the two ES variants (classical-type and proximal-type) in order gain a better understanding of the disease, tailor the treatment and lastly improve outcome.
Interventions
- Other Treatment for Epitheloid Sarcoma
Treatment Epitheloid Sarcoma according the disease guideline
Primary outcome measures
- Type of treatment given to patients with ES [Time frame: From diagnosis until the date of death from any cause assessed up to 60 months]
Secondary outcome measures (3)
- Radiotherapy treatments [Time frame: From the time of diagnosis and then every 6 months up to 60 months]
- Chemotherapy treatments [Time frame: From the time of diagnosis and then every 6 months up to 60 months]
- Predictive biomarkers for response [Time frame: At time of diagnosis and at the time of any progression where a biopsy is performed up to 60 months]
Eligibility criteria
Inclusion criteria
- Histological diagnosis of epithelioid sarcoma according to 2014 World Health Organization (WHO) classification, performed on biopsy or surgical specimen
- Signed informed consent
- Adequate patient compliance to treatment or follow up
- No age limit
Exclusion criteria
- Other malignancies within past 5 years, with exception of carcinoma in situ of the cervix and basocellular skin cancers treated with eradicating intent
- Impossibility to ensure adequate compliance
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Italy · 11 centers
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST — Meldola
- Istituto Europeo di Oncologia — Milan
- Istituto Clinico Humanitas — Rozzano
- Azienda Ospedaliera Universitaria Paolo Giaccone — Palermo
- Fondazione del Piemonte per l'Oncologia IRCC Candiolo — Candiolo
- Istituto Ortopedico Rizzoli - Unit of Chemotherapy of Muscoloskeletal Tumors — Bologna
- Fondazione IRCCS INT Milano — Milan
- Irccs Istituto Oncologico Veneto (Iov) — Padova
- … and 3 more centers
Publications
- Thway K, Jones RL, Noujaim J, Fisher C. Epithelioid Sarcoma: Diagnostic Features and Genetics. Adv Anat Pathol. 2016 Jan;23(1):41-9. doi: 10.1097/PAP.0000000000000102. PMID 26645461
- Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD. "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol. 1997 Feb;21(2):130-46. doi: 10.1097/00000478-199702000-00002. PMID 9042279
- Chase DR, Enzinger FM. Epithelioid sarcoma. Diagnosis, prognostic indicators, and treatment. Am J Surg Pathol. 1985 Apr;9(4):241-63. PMID 4014539
- Bos GD, Pritchard DJ, Reiman HM, Dobyns JH, Ilstrup DM, Landon GC. Epithelioid sarcoma. An analysis of fifty-one cases. J Bone Joint Surg Am. 1988 Jul;70(6):862-70. PMID 3392084
- Halling AC, Wollan PC, Pritchard DJ, Vlasak R, Nascimento AG. Epithelioid sarcoma: a clinicopathologic review of 55 cases. Mayo Clin Proc. 1996 Jul;71(7):636-42. doi: 10.1016/S0025-6196(11)63000-0. PMID 8656704
Identifiers
NCT: NCT03099681 · ISG-EPISObs