Cranial Nerves Tractography
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: preoperative cerebral MRI and operative findings.
- Who it may be relevant to
- Registry conditions: Cranial Nerve Palsy. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy
Overview
Introduction: The skull base tumors surgery remains a challenge since numerous cranial nerves or vessels closely surround them. Recently, diffusion tensor imaging has developed with the tractography following white fibers and visualizing functional tracts. Cranial nerves tractography could allow predicting their displacement by skull base tumors that may help the surgeon to spare them along the surgery. Methods: Preoperative cerebral MRI was performed on patients who presented with skull base tumors. A 3 tesla MRI machine was used to acquire DTI sequence with specific parameters: 32 directions, slice thickness 2 mm, echo time 86 ms, repetition time 12000 ms, matrix 128x128, b-value 1000 s.mm-1. An anatomic sequence hyperT2 was overlaid as reference. Distortion was corrected by topup and eddy functions from FSL. Cranial nerves fibers were probabilistically tracked with Mrtrix3. Cranial nerves were selected according to their location around the tumor. The "radiological" expected position of the cranial nerve was compared to its "operative" real position.
Interventions
- Procedure preoperative cerebral MRI and operative findings
Primary outcome measures
- Correlation between the expected and the real position of the selected cranial nerve [Time frame: Date of preoperative MRI (<3 months before the surgery)]
- Correlation between the expected and the real position of the selected cranial nerve [Time frame: at 3 months]
Secondary outcome measures (1)
- postoperative cranial nerve palsy [Time frame: at 3 months]
Eligibility criteria
Inclusion criteria
- Patients who present a skull base tumor that requires surgical removal
- Patients adult, informed and agreed
Exclusion criteria
- Pregnant women
- Patients under 18 years old, unable to legally consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
France · 1 center
- Service de Neurologie B, Hôpital Neurologique, HCL — Bron
Identifiers
NCT: NCT02978911 · 69HCL16_0759 · 2015-A01113-46