Recruiting NCT02902198
Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Placebo, Glucose, Monosodium glutamate, Quinine.
- Who it may be relevant to
- Registry conditions: Obesity. Basic parameters: 18 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
Interventions
- Dietary supplement Placebo
Tap water 200ml - Dietary supplement Glucose
25g Glucose in 200ml tap water - Dietary supplement Monosodium glutamate
1g monosodium glutamate in 200ml tap water - Dietary supplement Quinine
17mg quinine in 200ml tap water
Primary outcome measures
- Effect of tastants on cerebral blood flow measured by functional brain MRI [Time frame: changes from baseline to one hour after treatment]
Secondary outcome measures (2)
- Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations [Time frame: changes from baseline to one hour after treatment]
- Effect of tastants plasma ghrelin concentrations [Time frame: changes from baseline to one hour after treatment]
Eligibility criteria
Inclusion criteria
- morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
- right handed
Exclusion criteria
- cardiovascular disease
- neurologic/psychiatric disorders
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
Switzerland · 1 center
- University Hopital Basel — Basel
Identifiers
NCT: NCT02902198 · fMRI Taste 2