Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Myocardial Infarction. Basic parameters: 21 years — 69 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Singapore
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
SingHEART: Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
Overview
A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations
Detailed description
SingHEART sub-study will collect the following data types or perform the following investigations:
1. Demographic and clinical characteristics data. 2. Basic blood investigations. Basic blood investigations include: FBC, CRP, renal panel, random glucose, LFT, fasting lipids, ESR, CRP, 3. Perform a single baseline cardiac MRI (already consented and obtained as part of the primary study). 4. ECG 5. Calcium score 6. Biobanking (whole blood, plasma and serum, already performed as part of the primary study) 7. Exercise and physical activity tracker over two 1-week periods 8. Ambulatory BP monitoring over two 24-48H periods
Primary outcome measures
- First cardiovascular event [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Men and women age 21-69 years
Exclusion criteria
- Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
- Known coronary artery disease - prior coronary revascularization
- Known documented peripheral arterial disease
- Previous stroke
a. Stroke is defined as new focal neurological deficit persisting more than 24hours21.
- More than ongoing use of 2 or more anti-hypertensive agents
- Prior history of cancer (excludes pre-cancerous lesions)
- Expected life expectancy less than 1 year
- Known definite diabetes mellitus or on treatment for diabetes mellitus
- Known autoimmune disease or genetic disease
- Known endocrine disease on treatment
- Psychiatric illness
- Asthma or chronic lung disease requiring long term medications or oxygen
- Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
- Inability to comply with study protocol
- Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Singapore · 1 center
- National Heart Centre Singapore — Singapore
Publications
- Bylstra Y, Lim WK, Teo JX, Menezes M, Hodgson J, Yap F, Chambers JC, Yeo KK, Tan P, Amor DJ, Jamuar SS. Unexpected genotypes associated with severe paediatric conditions identified in a healthy population cohort. Eur J Hum Genet. 2026 Mar;34(3):368-378. doi: 10.1038/s41431-025-02009-2. Epub 2026 Jan 10. PMID 41520097
- Bylstra Y, Lim WK, Kam S, Tham KW, Wu RR, Teo JX, Davila S, Kuan JL, Chan SH, Bertin N, Yang CX, Rozen S, Teh BT, Yeo KK, Cook SA, Jamuar SS, Ginsburg GS, Orlando LA, Tan P. Family history assessment significantly enhances delivery of precision medicine in the genomics era. Genome Med. 2021 Jan 7;13(1):3. doi: 10.1186/s13073-020-00819-1. PMID 33413596
Identifiers
NCT: NCT02791152 · 2015/2601