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Recruiting NCT02784977

TURKAPNE - The Turkish Sleep Apnea Database: A National, Multicenter, Observational, Prospective Cohort Study

— Observational Obstructive Sleep Apnea

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An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Positive Airway Pressure (PAP), Intraoral device (IOD), Uvuloplasty, Conservative treatment.
Who it may be relevant to
Registry conditions: Obstructive Sleep Apnea. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

Primary aim of the TURKAPNE (The Turkish Sleep Apnea Database) study is to generate a cross-sectional nationwide database to define clinical and polysomnographic characteristics of the sleep apnea patients in Turkey. Associations of phenotypes of sleep apnea patients with metabolic and cardiovascular diseases as well as risk for traffic accidents will be explored as secondary aims. Impact of treatment of sleep apnea on metabolic and cardiovascular complications as well as compliance with positive airway pressure treatment will be further explored longitudinally.

Detailed description

All subjects undergoing sleep study for suspicion of obstructive sleep apnea will be registered in a web-based national database regarding:

* Anthropometric data, educational status, driving licence, * Smoking and alcohol use * Comorbidities, and drug use * Questionnaires, excessive daytime sleepiness * Polygraphic and polysomnographic findings * Blood pressure measurements * If taken, blood glucose, lipids and other biochemical markers * If measured, lung function test results * If measured, echocardiography findings * Follow-up data regarding treatment modality and compliance

Interventions

  • Device Positive Airway Pressure (PAP)
    Treatment of OSA with PAP
  • Device Intraoral device (IOD)
    Treatment of OSA with IOD
  • Procedure Uvuloplasty
    Uvuloplasty
  • Other Conservative treatment
    No active intervention

Primary outcome measures

  • Metabolic and cardiovascular diseases in obstructive sleep apnea phenotypes [Time frame: Up to three years]
Secondary outcome measures (3)
  • Sex differences in obstructive sleep apnea phenotypes [Time frame: Up to three years]
  • Adherence to positive airway pressure treatment in obstructive sleep apnea [Time frame: Through study completion, an average of 7 years]
  • Incidence of cardiovascular diseases and mortality [Time frame: Through study completion, an average of 7 years]

Eligibility criteria

Inclusion criteria

  • Consecutive adult patients undergoing sleep study for suspicion of obstructive sleep apnea
  • Ability to read and speak
  • Signed informed consent.

Exclusion criteria

  • subjects who use positive airway pressure
  • subjects with limited life expectancy due to advanced renal disease or uncontrolled malignancies
  • subjects with alcohol dependency

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Turkey (Türkiye) · 1 center
  • Koç University Hospital — Istanbul

Publications

  • Peker Y, Basoglu OK, Firat H; TURKAPNE Study Group. Rationale and Design of the Turkish Sleep Apnea Database - TURKAPNE: A National, Multicenter, Observational, Prospective Cohort Study. Turk Thorac J. 2018 Jul;19(3):136-140. doi: 10.5152/TurkThoracJ.2018.18097. Epub 2018 Jul 1. PMID 30083405
  • Gurkan CG, Pihtili A, Kiyan E, Tasbakan MS, Basoglu OK, Arbatli S, Aydin S, Cilli A, Dursunoglu N, Baran B, Peker Y; Turkapne Study Group. Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort. J Clin Sleep Med. 2026 Jul 2;22(1):103. doi: 10.1007/s44470-026-00109-4. PMID 42390661
  • Pihtili A, Kiyan E, Balcan B, Arbatli S, Cilli A, Altintas N, Ugurlu AO, Gurkan CG, Tasbakan MS, Dursunoglu N, Ogun H, Annakkaya AN, Sokucu SN, Firat H, Basoglu OK, Peker Y; Turkapne Study Group. Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort. Sleep Med. 2025 Feb;126:228-234. doi: 10.1016/j.sleep.2024.12.018. PMID 39721358

Identifiers

NCT: NCT02784977 · 09.2016.311

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗